Artemisinin-Based and Other Antimalarials

Detailed Account of Studies by Chinese Scientists Who Discovered and Developed Them
Erscheinungsjahr 2017
ISBN: 978-0-12-813133-6
Verlag: Elsevier Science

Buch, Englisch, 736 Seiten, Format (B × H): 191 mm x 235 mm, Gewicht: 1130 g

Artemisinin-Based and Other Antimalarials: Detailed Account of Studies by Chinese Scientists Who Discovered and Developed Them provides a historical and scientific background of the discovery and development of artemisinin, artemisinin derivatives, combination drugs and related chemicals. It is a historical document, a scientific treatise, and a fascinating description of innovative research on new drug development that is carried out under extremely difficult conditions. The book also includes detailed experiments, physical-chemical procedures, practical methodologies and clinical trials. It is a valuable reference for students and researchers in the fields of scientific history, medicine, pharmaceutical science, chemistry, pharmacology and toxicology.

Zielgruppe

<p>Historians, drug developers, scientists of many disciplines, students in pharmacology, medicine<b> </b>and chemistry and interested general readers but especially anyone interested in malaria of whatever background</p>

Autoren/Hrsg.

Li, Guoqiao

Li, Zelin

Li, Ying

Zeng, Meiyi

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Geschichte der Medizin

Inhaltsverzeichnis

1. Discovery of Artemisinin and History of Research and Discovery of Artemisinin Antimalarials2. Biological Research of Artemisia annua L 3. Chemical Research on Artemisinin4. Artemisinin Derivatives and Analogues5. Pharmacological Study on Artemisinin and Its Derivatives6. Clinical Studies of Artemisinin and its Derivatives7. Artemether and Lumefantrine Combination 8. Artemisinin and Naphthoquine Phosphate Combination9. The Combination of Artemisinin Drugs and Pyronaridine10. Artemisinins and piperaquine phosphate combinations

Über Autor(innen)

Li, Zelin
Professor Li graduated from College of Pharmacology, Shanghai First Medical University in 1953. Li was a specialist dispatched by Division of Traditional Medicine, West Pacific Regional Office, WHO to give lecture on developing new drugs originating from herbal drugs in Vietnam in 1990. She identified the action site of plasmodium with electromicroscope autoradiography technology. She also identified that artemisinin series compounds could inhibit the metabolism of nucleic acid in plasmodium with in vitro culture. Li was engaged in studies on the pharmacodynamics, pharmacokinetics and special toxicity, such as teratogenicity and mutagenicity of artemisinim. Ms. Li was one of the main secretaries of the China Steering Committee of Qinghaosu, participating the design of the project and coordinating the work of individual research group to develop new anti-malaria drugs.

Zeng, Meiyi
Professor Zeng graduated from Faculty of Pharmaceutical Sciences, College of Medicine, Beijing University in1954 with diploma, 1954-1990 worked in the Department of Analytical Chemistry of Institute of Chinese Materia Medica under Academy of Traditional Chinese Medicine, with more than 35 years' experience in chemical analysis.
Professor Zeng developed the assay method for quality control of qinghaosu (artemisinin), and method for determination of dihydroartemisinin and improving method for assay of artemether in pharmaceutical substance. In 1986, Zhao Shishan and Zeng developed the HPLC method for determination of artemisinin in animal and human plasma and applied to analysis of plasma samples of falciparum patients after rectal administration of artemisinin suppositories