Li / Corey Drug Discovery

Practices, Processes, and Perspectives
1. Auflage 2013
ISBN: 978-1-118-35447-6
Verlag: John Wiley & Sons
Format: EPUB
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 570 Seiten, E-Book

Sets forth the history, state of the science, and future directions of drug discovery
Edited by Jie Jack Li and Nobel laureate E. J. Corey, two leading pioneers in drug discovery and medicinal chemistry, this book synthesizes great moments in history, the current state of the science, and future directions of drug discovery into one expertly written and organized work. Exploring all major therapeutic areas, the book introduces readers to all facets and phases of drug discovery, including target selection, biological testing, drug metabolism, and computer-assisted drug design.
Drug Discovery features chapters written by an international team of pharmaceutical and medicinal chemists. Contributions are based on a thorough review of the current literature as well as the authors' firsthand laboratory experience in drug discovery. The book begins with the history of drug discovery, describing groundbreaking moments in the field. Next, it covers such topics as:
* Target identification and validation
* Drug metabolism and pharmacokinetics
* Central nervous system drugs
* In vitro and in vivo assays
* Cardiovascular drugs
* Cancer drugs
Each chapter features a case study, helping readers understand how science is put into practice throughout all phases of drug discovery. References at the end of each chapter serve as a gateway to groundbreaking original research studies and reviews in the field.
Drug Discovery is ideal for newcomers to medicinal chemistry and drug discovery, providing a comprehensive overview of the field. Veterans in the field will also benefit from the perspectives of leading international experts in all aspects of drug discovery.

Autoren/Hrsg.

Li, Jie Jack

Corey, E. J.

Über Autor(innen)

JIE JACK LI, PhD, is a chemist at Bristol-Myers SquibbCompany. He has authored or edited several books published byWiley, including Name Reactions in Heterocyclic Chemistry, NameReactions for Functional Group Transformations, Name Reactions forHomologations (Part I and Part II), Name Reactions forCarbocyclic Ring Formations, Contemporary Drug Synthesis, The Artof Drug Synthesis, and Modern Drug Synthesis.
E. J. COREY, PhD, has been a Professor at HarvardUniversity since 1959. The 1990 Nobel Laureate in Chemistry, Dr.Corey has also been the recipient of more than seventyinternational awards and honorary degrees, including the U.S.National Medal of Science, the Japan Prize in Science, and thePriestley Medal. Author of more than 1,500 publications, he is oneof the most cited authors in science.