Metabolic Engineering

Concepts and Applications
1. Auflage 2021
ISBN: 978-3-527-34662-2
Verlag: Wiley-VCH GmbH

Buch, Englisch, 976 Seiten, Format (B × H): 177 mm x 251 mm, Gewicht: 2118 g

Reihe: Advanced biotechnology

Learn more about foundational and advanced topics in metabolic engineering in this comprehensive resource edited by leaders in the field

Metabolic Engineering: Concepts and Applications delivers a one-stop resource for readers seeking a complete description of the concepts, models, and applications of metabolic engineering. This guide offers practical insights into the metabolic engineering of major cell lines, including E. Coli, Bacillus and Yarrowia Lipolytica, and organisms, including human, animal, and plant). The distinguished editors also offer readers resources on microbiome engineering and the use of metabolic engineering in bioremediation.

Written in two parts, Metabolic Engineering begins with the essential models and strategies of the field, like Flux Balance Analysis, Quantitative Flux Analysis, and Proteome Constrained Models. It also provides an overview of topics like Pathway Design, Metabolomics, and Genome Editing of Bacteria and Eukarya.

The second part contains insightful descriptions of the practical applications of metabolic engineering, including specific examples that shed light on the topics within. In addition to subjects like the metabolic engineering of animals, humans, and plants, you’ll learn more about:

- Metabolic engineering concepts and a historical perspective on their development
- The different modes of analysis, including flux balance analysis and quantitative flux analysis
- An illuminating and complete discussion of the thermodynamics of metabolic pathways
- The Genome architecture of E. coli, as well as genome editing of both bacteria and eukarya
- An in-depth treatment of the application of metabolic engineering techniques to organisms including corynebacterial, bacillus, and pseudomonas, and more

Perfect for students of biotechnology, bioengineers, and biotechnologists, Metabolic Engineering: Concepts and Applications also has a place on the bookshelves of research institutes, biotechnological institutes and industry labs, and university libraries. It's comprehensive treatment of all relevant metabolic engineering concepts, models, and applications will be of use to practicing biotechnologists and bioengineers who wish to solidify their understanding of the field.

Autoren/Hrsg.

Lee, Sang Yup

Nielsen, Jens

Stephanopoulos, Gregory

Weitere Mitwirkende

Lee, Sang Yup

Nielsen, Jens

Stephanopoulos, Gregory

Fachgebiete

• Naturwissenschaften Biowissenschaften Zellbiologie
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Biotechnologie
• Naturwissenschaften Biowissenschaften Molekularbiologie

Inhaltsverzeichnis

Part I - Concepts
 
1 Metabolic Engineering Perspectives
2 Genome-Scale Models: Two Decades of Progress and a 2020 Vision
3 Quantitative Metabolic Flux Analysis Based on Isotope Labeling
4 Proteome Constraints in Genome-Scale Models
5 Kinetic Models of Metabolism
6 Metabolic Control Analysis
7 Thermodynamics of Metabolic Pathways
8 Pathway Design
9 Metabolomics
10 Genome Editing of Eukarya
 
Part II - Applications
 
11 Metabolic Engineering of Escherichia coli
12 Metabolic Engineering of Corynebacterium glutamicum
13 Metabolic Engineering of Bacillus - New Tools, Strains, and Concepts
14 Metabolic Engineering of Pseudomonas
15 Metabolic Engineering of Lactic Acid Bacteria
16 Metabolic Engineering and the Synthetic Biology Toolbox for Clostridium
17 Metabolic Engineering of Filamentous Actinomycetes
18 Metabolic Engineering of Yeast
19 Harness Yarrowia lipolytica to Make Small Molecule Products
20 Metabolic Engineering of Filamentous Fungi
21 Metabolic Engineering of Photosynthetic Cells ? in Collaboration with Nature
22 Metabolic Engineering for Large-Scale Environmental Bioremediation
 

Über Autor(innen)

Sang Yup Lee is Distinguished Professor at the Department of Chemical and Biomolecular Engineering at the Korea Advanced Institute of Science and Technology (KAIST). He is currently the Director of the Center for Systems and Synthetic Biotechnology, Director of the BioProcess Engineering Research Center, and Director of the Bioinformatics Research Center. He has published more than 500 journal papers, 64 books and book chapters, and more than 580 patents (either registered or applied). He received numerous awards, including the National Order of Merit, the Merck Metabolic Engineering Award, the ACS Marvin Johnson Award, Charles Thom Award, Amgen Biochemical Engineering Award, Elmer Gaden Award, POSCO TJ Park Prize, and HoAm Prize. He currently is Fellow of American Association for the Advancement of Science, the American Academy of Microbiology, American Institute of Chemical Engineers, Society for Industrial Microbiology and Biotechnology, American Institute of Medical and Biological Engineering, the World Academy of Science, the Korean Academy of Science and Technology, and the National Academy of Engineering of Korea. He is also Foreign Member of National Academy of Engineering USA. He is currently honorary professor of the University of Queensland (Australia), honorary professor of the Chinese Academy of Sciences, honorary professor of Wuhan University (China), honorary professor of Hubei University of Technology (China), honorary professor of Beijing University of Chemical Technology (China), and advisory professor of the Shanghai Jiaotong University (China). Lee is the Editor-in-Chief of the Biotechnology Journal and Associate Editor and board member of numerous other journals. Lee is currently serving as a member of Presidential Advisory Committee on Science and Technology (Korea).
 
Jens Nielsen is Professor and Director to Chalmers University of Technology (Sweden) since 2008. He obtained an MSc degree in Chemical Engineering and a PhD degree (1989) in Biochemical Engineering from the Technical University of Denmark (DTU) and after that established his independent research group and was appointed full Professor there in 1998. He was Fulbright visiting professor at MIT in 1995-1996. At DTU, he founded and directed the Center for Microbial Biotechnology. Jens Nielsen has published more than 350 research papers, co-authored more than 40 books and he is inventor of more than 50 patents. He has founded several companies that have raised more than 20 million in venture capital. He has received numerous Danish and international awards and is member of the Academy of Technical Sciences (Denmark), the National Academy of Engineering (USA), the Royal Danish Academy of Science and Letters, the American Institute for Medical and Biological Engineering and the Royal Swedish Academy of Engineering Sciences.
 
Professor Gregory Stephanopoulos is the W. H. Dow Professor of Chemical Engineering at the Massachusetts Institute of Technology (MIT, USA) and Director of the MIT Metabolic Engineering Laboratory. He is also Instructor of Bioengineering at Harvard Medical School (since 1997). He received his BS degree from the National Technical University of Athens and his PhD from the University of Minnesota (USA). He has co-authored approximately 400 research papers and 50 patents, along with the first textbook on Metabolic Engineering. He has been recognized by numerous awards from the American Institute of Chemical Engineers (AIChE) (Wilhelm, Walker and Founders awards), American Chemical Society (ACS), Society of industrial Microbiology (SIM), BIO (Washington Carver Award), the John Fritz Medal of the American Association of Engineering Societies, and others. In 2003 he was elected member of the National Academy of Engineering (USA) and in 2014 President of AIChE.