Buch, Englisch, Band 89, 154 Seiten, Format (B × H): 158 mm x 225 mm
Buch, Englisch, Band 89, 154 Seiten, Format (B × H): 158 mm x 225 mm
Reihe: Dresdner Beiträge zur Sensorik
ISBN: 978-3-95908-324-9
Verlag: TUDpress
The reliable quantitative detection of biomarkers and pathogens at picomolar or even
lower concentration is not readily available outside medical labs, yet, but would be a
great help for point-of-need/point-of-care testing (POCT). However, such detection
technologies are subject to extensive research. Microdevices based on integrated
optical waveguides are candidates for the detection of such ultra-low biochemical
concentrations.
In this work, sensors in the shape of microring or microracetrack resonators, manufactured
by UV-assisted nanoimprint lithography (UV-NIL) as a promising but challenging
replication technology, are investigated. Analytical and numeric models are
developed and the main influence factors that allow a low limit of detection, such
as the coupling gap width, the material shrinkage and the residual layer thickness,
are identified and quantified. Potential biosensor applications are evaluated and
general design rules as well as resulting designs are derived. The UV-NIL polymer
and the more established silicon-based microresonators are compared in terms of
technological parameters such as lithography resolution, integration level as well as
the dynamic measurement range.
High quality factors of Q > 25 000 were reached for free spectral ranges of FSR =
1.3nm and of Q > 13 000 for FSR = 2.0 nm, allowing both a high resolution of the
resonance shift detection and a sufficient dynamic range. The bulk refractive index
sensitivity was measured to be (60 ± 4)nm/RIU (refractive index units) which was
very close to the theoretical simulation of 63nm/RIU.
When comparing the results of this work to literature results, a very good sensor
performance was accomplished: A high dynamic range together with a good bulk
refractive index sensitivity was achieved for a technology with a fast throughput
time. Regarding the possibility to further increase the sensitivities by one to two
orders of magnitude through layout optimization and the fact that only two main
manufacturing steps were necessary, the UV-NIL polymer waveguide technology of
this work has a high potential for miniaturized, high-sensitivity biosensing.
Methods how to functionalize the microresonator sensors are tested and an alternative
biosensor characterisation assay is suggested. Ideas how to integrate the
microresonators into a biosensor system are investigated.
Landgraf
Polymer-Optical Waveguides for Biosensing jetzt bestellen!
lower concentration is not readily available outside medical labs, yet, but would be a
great help for point-of-need/point-of-care testing (POCT). However, such detection
technologies are subject to extensive research. Microdevices based on integrated
optical waveguides are candidates for the detection of such ultra-low biochemical
concentrations.
In this work, sensors in the shape of microring or microracetrack resonators, manufactured
by UV-assisted nanoimprint lithography (UV-NIL) as a promising but challenging
replication technology, are investigated. Analytical and numeric models are
developed and the main influence factors that allow a low limit of detection, such
as the coupling gap width, the material shrinkage and the residual layer thickness,
are identified and quantified. Potential biosensor applications are evaluated and
general design rules as well as resulting designs are derived. The UV-NIL polymer
and the more established silicon-based microresonators are compared in terms of
technological parameters such as lithography resolution, integration level as well as
the dynamic measurement range.
High quality factors of Q > 25 000 were reached for free spectral ranges of FSR =
1.3nm and of Q > 13 000 for FSR = 2.0 nm, allowing both a high resolution of the
resonance shift detection and a sufficient dynamic range. The bulk refractive index
sensitivity was measured to be (60 ± 4)nm/RIU (refractive index units) which was
very close to the theoretical simulation of 63nm/RIU.
When comparing the results of this work to literature results, a very good sensor
performance was accomplished: A high dynamic range together with a good bulk
refractive index sensitivity was achieved for a technology with a fast throughput
time. Regarding the possibility to further increase the sensitivities by one to two
orders of magnitude through layout optimization and the fact that only two main
manufacturing steps were necessary, the UV-NIL polymer waveguide technology of
this work has a high potential for miniaturized, high-sensitivity biosensing.
Methods how to functionalize the microresonator sensors are tested and an alternative
biosensor characterisation assay is suggested. Ideas how to integrate the
microresonators into a biosensor system are investigated.
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