Lahiri / Cherniak / Fitzgerald Response and Adaptation to Hypoxia

Organ to Organelle
Erscheinungsjahr 2013
ISBN: 978-1-4614-7574-3
Verlag: Springer US
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 264 Seiten, Web PDF

Reihe: Clinical Physiology

The underlying theme of this book is the biology of oxygen. The 22 chapters cover aspects of molecular, cellular, and integrative physiological functions. A fundamental evolutionary feature of the oxygen-consuming organism is that it developed a oxygen-sensing mechanism as apart of feedback control at the levels of molecules, organelles, organs, and systems. Oxygen sensing is partic ularly expressed in certain specific cells and tissues like peripheral chemore ceptors, erythroprotein-producing cells, and vascular smooth muscle. Apart of the book is focused on the current issues of this basic question of chemosen sing. Mitrochondria as the major site for cellular oxygen consumption is a nat ural candidate for cellular oxygen sensitivity and adaptation. A section deals with this question. A perennial question concerns chronic environment al oxy gen and the organism's response and adaptation to it. This theme runs through several chapters. Because comparative physiology often provides insight into the mechanisms of environment al adaptation, a chapter on respiration of high altitude birds has been incorporated. Obviously this book gives only glimpses of the immense field of oxygen biology. The book grew out of two meetings where these subjects were discussed. These meetings were sponsored by the American Physiological Society and the Federation of American Societies for Experimental Biology. We are grateful to the FASEB Program Committee and APS publication committee for their sup port. We owe much to Ms. Anne Miller for her editorial assistance. S. L. Philadelphia N. S . C. Cleveland R. S. F.

Zielgruppe

Research

Autoren/Hrsg.

Lahiri, Sukhamay

Cherniak, Neil S

Fitzgerald, Robert S

Inhaltsverzeichnis

I. Mitochondrial Response and Adaptation to Hypdxia.- 1. Respiratory System Adaptation to Hypoxia: Lung to Mitochondria.- 2. Factors Affecting Adaptation of the Mitochondrial Enzyme Content to Cellular Needs.- 3. Regulation of Mitochondrial Distribution: An Adaptive Response to Changes in Oxygen Supply.- II. Cell and Molecular Biology of Erythropoietin.- 4. Control of the Production of Erythropoietin by a Renal Oxygen-Sensor?.- 5. Hypoxia and Erythropoietin Production.- 6. Regulating Mechanisms Involved in the Expression of the Erythropoietin Gene.- 7. Expression of the Erythropoietin Gene in the Kidney and the Liver of the Anemic Mouse.- III. Cell Biology and Functions of Peripheral Chemoreceptors.- 8. Oxygen Sensing by Arterial Chemoreceptors.- 9. Oxygen Biology of Peripheral Chemoreceptors.- 10. Excitatory and Inhibitory Influences on the Ventilatory Augmentation Caused by Hypoxia.- 11. Control of Ventilation in Chronic Hypoxia: Role of Peripheral Chemoreceptors.- 12. Molecular Mechanisms of Carotid Body Afferent Neuron Development.- 13. Relationship between Erythropoiesis and Ventilation in High Altitude Natives.- IV. Oxygen Biology of Adaptation.- 14. Geometrical Relationship Between Capillaries and Muscle Fibers in Chronic Hypoxia.- 15. Muscle Function at Altitude.- 16. Acclimatization and Adaptation: Organ to Cell.- 17. Inborn Resistance to Hypoxia in High Altitude Adapted Humans.- 18. Differences in Pulmonary and Systemic Arterial Endothelial Cell Adaptation to Chronic Hypoxia.- 19. Pulmonary Hypoxic Vasoconstrictor Response: Modulation by the Peripheral Arterial Chemoreceptors.- 20. The Renin—Angiotensin—Aldosterone System during Hypoxia.- 21. Hypoxic Birds: Temperature and Respiration.- 22. Central Adaptation to Hypoxia.