Multiscale Mechanobiology in Tissue Engineering

1. Auflage 2019
ISBN: 978-981-10-8074-6
Verlag: Springer Nature Singapore

Buch, Englisch, Band 3, 203 Seiten, HC runder Rücken kaschiert, Format (B × H): 160 mm x 241 mm, Gewicht: 500 g

Reihe: Frontiers of Biomechanics

This book focuses on the mechanobiological principles in tissue engineering with a particular emphasis on the multiscale aspects of the translation of mechanical forces from bioreactors down to the cellular level. The book contributes to a better understanding of the design and use of bioreactors for tissue engineering and the use of mechanical loading to optimize in vitro cell culture conditions. It covers experimental and computational approaches and the combination of both to show the benefits that computational modelling can bring to experimentalists when studying in vitro cell culture within a scaffold. With topics from multidisciplinary fields of the life sciences, medicine, and engineering, this work provides a novel approach to the use of engineering tools for the optimization of biological processes and its application to regenerative medicine. The volume is a valuable resource for researchers and graduate students studying mechanobiology and tissue engineering. For undergraduate students it also provides deep insight into tissue engineering and its use in the design of bioreactors. The book is supplemented with extensive references for all chapters to help the reader to progress through the study of each topic.

Zielgruppe

Research

Autoren/Hrsg.

Lacroix, Damien

Brunelli, Marzia

Perrault, Cécile

Barreto, Sara

Baldit, Adrien

Shariatzadeh, Maryam

Campos Marin, Ana

Castro, Andre

Fachgebiete

• Naturwissenschaften Physik Angewandte Physik Biophysik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Medizintechnik, Biomedizintechnik, Medizinische Werkstoffe
• Technische Wissenschaften Maschinenbau | Werkstoffkunde Technische Mechanik | Werkstoffkunde Kontinuumsmechanik
• Naturwissenschaften Biowissenschaften Zellbiologie
• Naturwissenschaften Biowissenschaften Angewandte Biologie Biophysik
• Technische Wissenschaften Sonstige Technologien | Angewandte Technik Medizintechnik, Biomedizintechnik

Inhaltsverzeichnis

A review of bioreactors and mechanical stimuli.- Multiscale simulation of bioreactor design and in vitro conditions.- Mechanical stimulation in a PCL additive manufacturing scaffold.- Towards a new approach to analyse quality control and morphometric variability in a scaffold.- Computational simulation of cell seeding in a tissue engineering scaffold.- Collagen gel cell encapsulation to study mechanotransduction.- Collagen gel cell encapsulation to study the effect of fluid flow on mechanotransduction.- Computational modeling of collagen hydrogel.- Mechanical load transfer at the cellular level.- Quantification of CSK mechanics and deformation in relation to cellular functioning.- The future of tissue engineering design for bioreactor stimulation.

Über Autor(innen)

Damien Lacroix, INSIGNEO Institute for in silico Medicine, University of Sheffield, UKMarzia Brunelli, INSIGNEO Institute for in silico Medicine, University of Sheffield, UKCecile Perrault, INSIGNEO Institute for in silico Medicine, University of Sheffield, UKAdrien Baldit, INSIGNEO Institute for in silico Medicine, University of Sheffield, UKMaryam Shariatzadeh, INSIGNEO Institute for in silico Medicine, University of Sheffield, UKAna Campos Marin, INSIGNEO Institute for in silico Medicine, University of Sheffield, UKAndre Castro, INSIGNEO Institute for in silico Medicine, University of Sheffield, UKSara Barreto, INSIGNEO Institute for in silico Medicine, University of Sheffield, UK