Kumar / O'Rahilly Insulin Resistance

Insulin Action and its Disturbances in Disease
1. Auflage 2005
ISBN: 978-0-470-01126-3
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 616 Seiten, E-Book

Diabetes is now one of the major causes of morbidity worldwide. Inmany cases, the onset of diabetes is progressive, developing via acondition of insulin resistance. This book considers thedevelopment of this condition, its consequences and clinical andtherapeutic aspects.
The book reviews the normal biology of insulin action on glucose,lipids and proteins. It considers the pathological basis forinsulin resistance in animal models and humans, and discusses theinfluence of heredity, dietary factors and exercise. Clinicalconsequences including dyslipidaemia, hypertension and polycysticovary syndrome, and therapeutic strategies for treatment are alsoexamined.
* Provides an expert review of the phenomenon of insulinresistance
* Brings together a host of recent research for the firsttime
* Written by leading experts in biological and clinical research

Autoren/Hrsg.

Kumar, Sudhesh

O'Rahilly, Stephen

Inhaltsverzeichnis

Preface.
List of Contributors
1. The Insulin Receptor and Downstream Signalling (KenSiddle).
2. Insulin-Mediated Regulation of Glucose Metabolism (DanielKonrad, Assaf Rudich and Amira Klip).
3. Insulin Action on Lipid Metabolism (Keith N. Frayn andFredrik Karpe).
4. The Effect of Insulin on Protein Metabolism (Laura J. S.Greenlund and K. Sreekumaran Nair).
5. Genetically Modified Mouse Models of Insulin Resistance(Gema Medina, Christopher Lelliott and Antonio J.Vidal-Puig).
6. Insulin Resistance in Glucose Disposal and Production in Manwith Specific Reference to Metabolic Syndrome and Type 2 Diabetes(Henning Beck-Nielsen, Frank Alford and OleHother-Nielsen).
7. Central Regulation of Peripheral Glucose Metabolism(Stanley M. Hileman and Christian Bjørbæk).
8. Relationship Between Fat Distribution and Insulin Resistance(Philip G. McTernan, Aresh Anwar and Sudhesh Kumar).
9. PPARy and Glucose Homeostasis (Robert K.Semple and Stephen O'Rahilly).
10. Adipokines and Insulin Resistance (Daniel K. Clarke andVidya Mohamed-Ali).
11. Dietary Factors and Insulin Resistance (Jeremy Krebs andSusan Jebb).
12. Physical Activity and Insulin Resistance (Nicholas J.Wareham, Søren Brage, Paul W. Franks and RebeccaAbbott).
13. Genetics of the Metabolic Syndrome (George Argyropoulos,Steven Smith and Claude Bouchard).
14. Insulin Resistance and Dyslipidaemia (BenoîtLamarche and Jean-François Mauger).
15. Insulin Resistance, Hypertension and Endothelial Dysfunction(Stephen J. Cleland and John M. C. Connell).
16. Insulin Resistance and Polycystic Ovary Syndrome (NeusPotau).
17. Syndromes of Severe Insulin Resistance (SSIRs) (DavidSavage and Stephen O'Rahilly).
18. Therapeutic Strategies for Insulin Resistance (Harpal S.Randeva, Margaret Clarke and Sudhesh Kumar).
19. Drug Therapy for Insulin Resistance - a Look at theFuture (Bei B. Zhang and David E. Moller).
Index.