Kuhlmann / Puls Oral Antidiabetics

Erscheinungsjahr 2013
ISBN: 978-3-662-09127-2
Verlag: Springer
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band 119, 733 Seiten, eBook

Reihe: Handbook of Experimental Pharmacology

The prevalence of diabetes continues to increase worldwide. Traditionally, diabetes in its adult form has not been considered a serious life-threatening disease. This attitude needs to be changed because the complications asso ciated with the adult form of diabetes affect almost every organ system. The high morbidity and mortality of non-insulin-dependent diabetes mellitus (NIDDM) suggest that current treatment strategies are unsatisfactory. We therefore face an urgent need for new therapeutic approaches. When the first Handbook 0/ Oral Antidiabetics was edited by H. Maske in 1971, the risks and benefits associated with the use of oral antidiabetics were still under discussion. Nowadays, oral antidiabetics hold a strong posi tion in the long-term treatment of diabetes. Roughly 30% -50% of the patients with diabetes in Europe and the United States are treated with oral antidiabetics, chiefly sulfonylureas. While acknowledging the value of the ß cytotropic sulfonylureas, we also need to recognize important limitations of their use, e.g., in the treatment of obese diabetic patients.

Zielgruppe

Professional/practitioner

Autoren/Hrsg.

Kuhlmann, Jochen

Puls, Walter

Inhaltsverzeichnis

1 Introduction.- 2 Pathophysiology of Type 2 Diabetes Mellitus.- 3 Non-Pharmacological Management of Non-Insulin-Dependent Diabetes.- Section I: Sulfonylureas.- 4 Sulfonylureas and Related Compounds: Chemistry and Structure-Activity Relationships.- 5 Sulfonylureas: Physicochemical Properties, Analytical Methods of Determination and Bioavailability.- 6 Mode of Action of Sulfonylureas.- 7 Sulfonylureas: Pharmacokinetics in Animal Experiments.- 8 Toxicology of Sulfonylureas.- 9 Clinical Pharmacology of Sulfonylureas.- Section II: Biguanides.- 10 Chemistry and Structure-Activity Relationships of Biguanides.- 11 Physicochemical Properties and Analytical Methods of Determination of Biguanides.- 12 Preclinical Pharmacology of Biguanides.- 13 Toxicology of Biguanides.- 14 Clinical Pharmacology of Biguanides.- Section III: Glucosidase Inhibitors.- 15 Chemistry and Structure-Activity Relationships of Glucosidase Inhibitors.- 16 Analytical Methods of Determination of Glucosidase Inhibitors.- 17 Pharmacology of Glucosidase Inhibitors.- 18 General Pharmacology of Glucosidase Inhibitors.- 19 Pharmacokinetics and Metabolism of Glucosidase Inhibitors.- 20 Toxicology of Glucosidase Inhibitors.- 21 Clinical Pharmacology of Glucosidase Inhibitors.- 22 Clinical Evaluation of Glucosidase Inhibitors.- 23 Oral Antidiabetic Drugs in Research and Development.- 24 New Approaches for the Treatment of Diabetes Mellitus.