IgM and Its Receptors and Binding Proteins

Softcover Nachdruck of the original 1. Auflage 2017
ISBN: 978-3-319-87810-2
Verlag: Springer

Buch, Englisch, 117 Seiten, Previously published in hardcover, Format (B × H): 155 mm x 235 mm, Gewicht: 2058 g

Reihe: Current Topics in Microbiology and Immunology

This volume reviews the current state of research on the IgM antibody and its multiple receptors and binding proteins. Interactions of the IgM ligands with these molecules are important for protection against infections as a first line of defense, as well as for regulation of immune responses to pathogens and self-antigens. The book includes up-to-date information on: (i) the phylogeny of three IgM-binding receptors [polymeric Ig receptor (pIgR), Fc receptor for both IgA and IgM (Fca/µR), and Fc receptor for IgM only (FcµR)]; (ii) the lymphocyte-restricted distribution and unique ligand-binding activity of FcµR; (iii) the definition and potential function of Fc receptor-like molecule A (FCRLA) as a resident endoplasmic reticulum protein that binds IgM, but also IgG and IgA; (iv) IgM antibody-mediated enhancement of humoral immune responses, highlighting the importance of complement and its receptors, (v) the numerous important roles of IgM natural antibodies in regulation of inflammation. It is an invaluable resource for researchers and clinicians alike.

Zielgruppe

Research

Autoren/Hrsg.

Kubagawa, Hiromi

Burrows, Peter D.

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Infektionskrankheiten
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Immunologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Rheumatologie, Muskelerkrankungen

Inhaltsverzeichnis

The appearance and diversification of receptors for IgM during vertebrate evolution..- Authentic IgM Fc Receptor (FcµR).- FCRLA - A resident endoplasmic reticulum protein that associates with multiple immunoglobulin isotypes in B lineage cells.- Specific IgM and regulation of antibody responses.- Role of Natural IgM autoantibodies (IgM- NAA) and IgM anti-leucocyte antibodies (IgM-ALA) in regulating inflammation.

Über Autor(innen)

Hiromi Kubagawa, MD, is presently Guest Senior Scientist at Deutsches Rheuma-Forschungszentrum, Berlin, Germany 
Peter D. Burrows, PhD,  is a professor at Dept. of Microbiology, University of Alabama at Birmingham, AL, USA