E-Book, Englisch, 456 Seiten
Reihe: Frontiers in Neuroscience
From Mouse to Man
E-Book, Englisch, 456 Seiten
Reihe: Frontiers in Neuroscience
ISBN: 978-1-4398-1210-5
Verlag: Taylor & Francis
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)
The success of molecular biology and the new tools derived from molecular genetics have revolutionized pain research and its translation to therapeutic effectiveness. Bringing together recent advances in modern neuroscience regarding genetic studies in mice and humans and the practicality of clinical trials, Translational Pain Research: From Mouse to Man effectively bridges the gap between basic research and patient care by humanely examining rodent models for pain associated with bone cancer, osteoarthritis, fibromyalgia, and cardiac episodes.
Distinguished Team of International Contributors
In addition to addressing the groundbreaking technical advances in tract tracing, endocannabinoids, cannabis, gene therapy, siRNA gene studies, and the role of glia, cytokines, P2X receptors and ATP, this book also presents cutting-edge information on:
- Nociceptor sensitization
- Muscle nociceptors and metabolite detection
- Visceral afferents in disease
- Innovative rodent model for bone cancer pain
- Highly specific receptor cloning
- Modular molecular mechanisms relevant to painful neuropathies
This sharply focused work also discusses unexpected discoveries derived from brain-imaging studies related to thalamic pain. Translational Pain Research covers the progress made toward bringing laboratory science (much of it at the molecular level) to our understanding of pain phenomena in humans, with the ultimate goal of reducing the suffering that often accompanies pain and its indirect consequences.
Zielgruppe
Researchers in neuroscience, neurobiology, physiology, psychiatry, neuropharmacology, molecular biology, genetics, and lab animal science.
Autoren/Hrsg.
Fachgebiete
Weitere Infos & Material
Painful Multi-Symptom Disorders: A Systems Perspective
C. Richard Chapman
Neurotrophic Factors and Nociceptor Sensitization
Michael P. Jankowski and H. Richard Koerber
The Role of Visceral Afferents in Disease
Julie A. Christianson and Brian M. Davis
Cancer Pain: From the Development of Mouse Models to Human Clinical Trials
Juan Miguel Jimenez Andrade and Patrick Mantyh
Therapeutic Targeting of Peripheral Cannabinoid Receptors in Inflammatory and Neuropathic Pain States
Igor Spigelman
Molecular Strategies for Therapeutic Targeting of Primary Sensory Neurons in Chronic Pain Syndromes
Ichiro Nishimura, Devang Thakor, Audrey Lin, Supanigar Ruangsri, and Igor Spigelman
Transgenic Mouse Models for the Tracing of "Pain" Pathways
Allan I. Basbaum and João M. Bráz
Cytokines in Pain
Veronica I. Shubayev, Kinshi Kato, and Robert R. Myers
Glial Modulation in Pain States: Translation into Humans
Ryan J. Horvath, Edgar Alfonso Romero-Sandoval, and Joyce A. De Leo
On the Role of ATP-Gated P2X Receptors in Acute, Inflammatory, and Neuropathic Pain
Estelle Toulme, Makoto Tsuda, Baljit S. Khakh, and Kazuhide Inoue
Myalgia and Fatigue: Translation from Mouse Sensory Neurons to Fibromyalgia and Chronic Fatigue Syndromes
Alan R. Light, Charles J. Vierck, and Kathleen C. Light
Reflex Autonomic Responses Evoked by Group III and IV Muscle Afferents
Jennifer L. McCord and Marc P. Kaufman
Central Pain as a Thalamocortical Dysrhythmia: A Thalamic Efference Disconnection?
Kerry D. Walton and Rodolfo R. Llinás
What Can Neuroimaging Tell Us about Central Pain?
D.S. Veldhuijzen, F.A. Lenz, S.C. LaGraize, and J.D. Greenspan
Human Brain Imaging Studies of Chronic Pain: Translational Opportunities
A. Vania Apkarian
Consideration of Pharmacokinetic Pharmacodynamic Relationships in the Discovery of New Pain Drugs
Garth T. Whiteside and Jeffrey D. Kennedy
Large Animal Models for Pain Therapeutic Development
Darrell A. Henze and Mark O. Urban
Drug Discovery and Development for Pain
Sandra R. Chaplan, William A. Eckert III, and Nicholas I. Carruthers
Index
