Computational Systems Biology

2. Auflage 2013
ISBN: 978-0-12-405926-9
Verlag: Elsevier Science & Technology

Buch, Englisch, 548 Seiten, Format (B × H): 194 mm x 241 mm, Gewicht: 1110 g

This comprehensively revised second edition of Computational Systems Biology discusses the experimental and theoretical foundations of the function of biological systems at the molecular, cellular or organismal level over temporal and spatial scales, as systems biology advances to provide clinical solutions to complex medical problems. In particular the work focuses on the engineering of biological systems and network modeling.

Zielgruppe

Graduate students and researchers in Bioinformatics, Biocomputing, Theoretical Biology, Biochemistry/Biophysics, and Cell Biology.

Autoren/Hrsg.

Kriete, Andres

Eils, Roland

Fachgebiete

• Naturwissenschaften Biowissenschaften Angewandte Biologie Biophysik
• Naturwissenschaften Biowissenschaften Angewandte Biologie Bioinformatik
• Mathematik | Informatik EDV | Informatik Angewandte Informatik Bioinformatik
• Naturwissenschaften Biowissenschaften Biowissenschaften
• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
• Naturwissenschaften Biowissenschaften Zellbiologie
• Naturwissenschaften Physik Angewandte Physik Biophysik

Inhaltsverzeichnis

Introducing Computational Systems Biology; Protein Interactions, Stability and Regulation; Transcriptional control; Introduction to Computational Models of Biochemical Reaction Networks; Biological Foundations of Signal Transduction and Aberrations in Disease; A discrete approach to top-down modeling of biochemical networks; Reconstruction of metabolic network from genome information and its structural and functional analysis; Gene networks: estimation, modeling and simulation; Standards, platforms and tools; Computational models for circadian rhythms: Deterministic versus stochastic approaches; Integrated imaging informatics; Imaging and Modeling of complex tumor formation; Imaging to help decipher an model higher orders of complexity; Multistability and multicellularity: cell fates as high-dimensional attractors of gene regulatory networks; Whole Cell Modeling; Databases for Systems Biology; Systems Biology of the Microbiome; Systems Immunology; Applying systems biology to understand the immune response to infection and vaccination; Aging and Systems Biology; From Cardiac Mitochondria to Systems Physiology; Cancer Systems Biology; Systems Medicine, Drug Biology and Interventions; Towards a blueprint of an entire organism

Über Autor(innen)

Eils, Roland
Professor of Bioinformatics at the University of Heidelberg and Director of the Division of Theoretical Bioinformatics at the German Cancer Research Center (DKFZ) in Heidelberg

Kriete, Andres
Associate Professor for Bioinformation Engineering at Drexel University, Philadelphia and Director of the Biocomputing Laboratory at the Coriell Institute for Medical Research