Design and Analysis of Biomolecular Circuits

Engineering Approaches to Systems and Synthetic Biology
2011. Auflage 2011
ISBN: 978-1-4419-6765-7
Verlag: Springer

Buch, Englisch, 402 Seiten, Format (B × H): 167 mm x 243 mm, Gewicht: 742 g

The book deals with engineering aspects of the two emerging and intertwined fields of synthetic and systems biology. Both fields hold promise to revolutionize the way molecular biology research is done, the way today’s drug discovery works and the way bio-engineering is done. Both fields stress the importance of building and characterizing small bio-molecular networks in order to synthesize incrementally and understand large complex networks inside living cells. Reminiscent of computer-aided design (CAD) of electronic circuits, abstraction is believed to be the key concept to achieve this goal. It allows hiding the overwhelming complexity of cellular processes by encapsulating network parts into abstract modules. This book provides a unique perspective on how concepts and methods from CAD of electronic circuits can be leveraged to overcome complexity barrier perceived in synthetic and systems biology.

Zielgruppe

Research

Autoren/Hrsg.

Koeppl, Heinz

Densmore, Douglas

Setti, Gianluca

di Bernardo, Mario

Fachgebiete

• Mathematik | Informatik EDV | Informatik Informatik Rechnerarchitektur
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Biotechnologie Biotechnologie: Mikrotechnologie, Nanobiotechnologie
• Interdisziplinäres Wissenschaften Wissenschaften Interdisziplinär Naturwissenschaften, Technik, Medizin
• Naturwissenschaften Biowissenschaften Angewandte Biologie Bioinformatik
• Mathematik | Informatik EDV | Informatik Angewandte Informatik Bioinformatik
• Technische Wissenschaften Elektronik | Nachrichtentechnik Elektronik Mikroprozessoren

Inhaltsverzeichnis

Simulation and Analysis of Bio-Molecular Circuits.- Introduction to Chemical Kinetics.- Computer Science Models to Describe Bio-Molecular Circuits.- Limitation of Current Modeling Approaches.-Abstraction in System Design; Abstraction Hierarchies and their use in CAD of Electronic Circuits.- Current efforts in standardization of Biological Parts.- Case Studies.-Biological Modules.- Enabling Technologies for Synthetic and Systems Biology.