Natural Products and Cancer Drug Discovery

2013
ISBN: 978-1-4614-4653-8
Verlag: Springer

Buch, Englisch, 244 Seiten, Format (B × H): 160 mm x 241 mm, Gewicht: 5089 g

Reihe: Cancer Drug Discovery and Development

This volume will cover the natural products as they relate to cancer chemotherapy. The topics will include history and current status, recent launches, new clinical candidates and approved drugs directly derived from natural products, current and future cancer target opportunities for natural products, leveraging natural products as tools for new target generation, new approaches to cancer drug discovery through natural products based lead generation, and enabling technologies which leverage the unique attributes of natural products.

Zielgruppe

Research

Autoren/Hrsg.

Koehn, Frank E.

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Onkologie, Krebsforschung
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Pharmazie

Inhaltsverzeichnis

Preface.-  The Impact of Natural Products upon Cancer Chemotherapy.- Identification and development of vascular disrupting agents: Natural products that interfere with tumor growth.- Discodermolide: Past, Present and Future.- HDAC Inhibitors and Other Histone Modifying Natural Products as Emerging Anticancer Agents .- Natural Product Cytotoxins As Payloads For Antibody Drug Conjugates.- Natural Product Scaffolds in Cancer Therapy.- The Role of Genetic Engineering in Natural Product-based Anticancer Drug Discovery.- Accessing Anti-Cancer Natural Products by Plant Cell Culture.- Natural Products as Tools for Discovering New Cancer Targets.- Index.