Kim / Pasternak Sigma Proteins: Evolution of the Concept of Sigma Receptors

1. Auflage 2017
ISBN: 978-3-319-65853-7
Verlag: Springer International Publishing
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 330 Seiten

Reihe: Handbook of Experimental Pharmacology

Provides an updated perspective on this rapidly evolving field undergoing changes in fundamental concepts of key importance to the discipline of pharmacology 

Emphasis is laid on the roles of sigma proteins in pathophysiology and on emergent therapeutic initiatives  

New investigators combined with more experienced investigators - as represented by the editors

Zielgruppe

Research

Autoren/Hrsg.

Kim, Felix J.

Pasternak, Gavril W.

Inhaltsverzeichnis

Preface.- Historical perspective and background - including Sigma protein subtypes and ligand selectivity.- Sigma imaging agents.- Medicinal chemistry.- 3-dimensional homology models of Sigma1.- Neuronal plasticity and ion channels.- Opioid receptors and other GPCR.- Cancer.- Neurodegenerative diseases.- Pain.- Cognition, learning, neurological disorders.- Drug abuse and addiction.- Alcohol Abuse.- Stroke and neuroprotection.

Über Autor(innen)

Felix J Kim PhD, Drexel University, College of Medicine, Pharmacology and Physiology, Philadelphia, USAGavril Pasternak MD Ph., Memorial Sloan-Kettering Cancer Center, Anne Burnett Tandy Chair in Neurology, Molec Pharmacology and Chemistry, New York, USA