Oocyte Biology in Fertility Preservation

Softcover Nachdruck of the original 1. Auflage 2013
ISBN: 978-1-4939-4574-0
Verlag: Springer

Buch, Englisch, 97 Seiten, Previously published in hardcover, Format (B × H): 155 mm x 235 mm, Gewicht: 1766 g

Reihe: Advances in Experimental Medicine and Biology

Fertility preservation has become one of the most important and fast growing fields of reproductive medicine. Although there
are several strategies for fertility preservation in female, most of them are still considered experimental. It is important to perfect the existing technologies, but also developing new strategies should be actively sought. The future development of fertility preservation strategies should be based on the sound scientific knowledge and principles.

One of the main objectives of fertility preservation in females is prevention of oocyte depletion. The mechanisms of oocyte loss and survival in the ovary are complex, which include genetic control both in germ cells and in somatic cells, DNA damage and repair mechanism, apoptosis and autophagy, and other poorly understood molecular mechanisms. To develop clinically effective and safe strategies for fertility preservation, it is essential to know and understand the fundamentals of oocyte and ovarian biology at the molecular level. Thus, the purpose of this edition is to review the current progress in research related to molecular and genetic control of oocyte development that can be applied to fertility preservation.  The main topics that are discussed in this publication include molecular signaling mechanisms of oocyte activation and loss, genomic integrity of oocytes, and epigenetics.

Zielgruppe

Research

Autoren/Hrsg.

Kim, S. Samuel

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Präventivmedizin, Gesundheitsförderung, Medizinisches Screening
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Molekulare Medizin, Zellbiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Gynäkologie, Geburtshilfe
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Reproduktionsmedizin

Inhaltsverzeichnis

The importance of oocyte biology for the future of fertility preservation.- The Control of Oocyte Survival by Intrinsic and Extrinsic Factors.- Oocyte Genomic Integrity.- In Vitro Activation of Dormant Follicles for Fertility Preservation.- Primate follicular development in vitro.- Vitrification of oocytes - From Basic Science to Clinical Application.- Memoir of Fertility Preservation.

Über Autor(innen)

S. Samuel Kim is on the editorial board of the Journal of Assisted Reproduction and Genetics, an official publication of the American Society for Reproductive Medicine. He works closely with the journal's Editor-in-Chief, David Albertini, at the University of Kansas Medical Center, with which they are both affiliated.