Khalili / Jeang Viral Oncology

Basic Science and Clinical Applications
1. Auflage 2010
ISBN: 978-0-470-93056-4
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 496 Seiten, E-Book

A comprehensive look at the latest research findings andclinical applications of oncogenic viruses
Written by a panel of academic experts, Viral Oncology isthe first self-contained and comprehensive book to present bothscientific and clinical information on viruses linked to some ofthe most important human cancers. Readers can turn to this book forthe most in-depth and up-to-date coverage of: HPV-associatedcancers; molecular events associated with HPV-induced human cancer;the role of the HPV E6 oncoprotein in malignant progression; virusassociation with brain tumors; involvement of the polyomavirus JCVin colorectal cancer; possibleassociation of BKV with prostatecancer; oncogenic transformation bypolyomavirus large T antigen;SV40 and human cancer; SV40 and mesothelioma; molecular immunologyof hepatitis B-associated viral cancer; hepatitis B vaccineand hepatocellular carcinoma; pathogenesis of acute and chronichepatitis Cvirus infection; molecular mechanisms of hepatitis Cvirus-induced cellulartransformation; clinical aspects of HTLV-1associated cancer; oncogenic potential of the HTLV-1 tax protein;HIV-associated malignancy; HIV-related lymphoma; biology andepidemiology of HHV-8; the role of KSHV in pathogenesis ofKaposi'ssarcoma; molecular pathobiology of EBV infection; and EBVas a pathogen.
Several chapters are devoted to the basic science of oncogenicviruses for thestudy of their pathogenesis, drug development, andemployment of viral vectorsfor vaccine and gene therapy. The bookalso includes complementary clinically based chapters describingnatural courses and treatments. Additionally, bonusclinicalmaterials are embedded within chapters and an easy-to-useindexcompletes the book.
Viral Oncology is an essential resource for clinical andresearch oncologists in medical facilities and biological researchlaboratories; clinicians and scientists working in relatedbiomedical areas; medical students working toward a first or higherdegree in the life sciences and other biomedical fields; andpharmaceutical scientists and developers.

Autoren/Hrsg.

Khalili, Kamel

Jeang, Kuan-Teh

Inhaltsverzeichnis

Foreword vii
Preface xi
Contributors xiii
1 HUMAN PAPILLOMAVIRUS-ASSOCIATED CANCERS 1
Rachel A. Katzenellenbogen and Denise A. Galloway
2 MOLECULAR EVENTS ASSOCIATED WITH HUMAN PAPILLOMAVIRUS-INDUCED HUMAN CANCERS 23
Amy Baldwin and Karl Münger
3 THE ROLE OF THE HUMAN PAPILLOMAVIRUS E6 ONCOPROTEIN IN MALIGNANT PROGRESSION 57
Miranda Thomas, David Pim, and Lawrence Banks
4 JC VIRUS ASSOCIATION WITH BRAIN TUMORS: THE ROLE OF T ANTIGEN AND INSULIN-LIKE GROWTH FACTOR 1 IN DNA REPAIR FIDELITY 89
Krzysztof Reiss, Kamel Khalili, and Luis Del Valle
5 INVOLVEMENT OF THE POLYOMAVIRUS, JC VIRUS, IN COLORECTAL CANCER 113
C. Richard Boland, Luigi Ricciardiello, and Ajay Goel
6 POSSIBLE ASSOCIATION OF BK VIRUS WITH PROSTATE CANCER 129
Michael J. Imperiale and Dweepanita Das
7 ONCOGENIC TRANSFORMATION BY POLYOMAVIRUS LARGE T ANTIGEN 149
Abhilasha V. Rathi and James M. Pipas
8 SIMIAN VIRUS 40, HUMAN INFECTIONS, AND CANCER: EMERGING CONCEPTS AND CAUSALITY CONSIDERATIONS 165
Janet S. Butel
9 SIMIAN VIRUS 40 AND MESOTHELIOMA 191
Natalya Baranova and Michele Carbone
10 MOLECULAR IMMUNOBIOLOGY OF HEPATITIS B-ASSOCIATED VIRAL CANCER 211
Timothy M. Block and Anand S. Mehta
11 HEPATITIS B VACCINE AND HEPATOCELLULAR CARCINOMA 225
Mei-Hwei Chang and Ding-Shinn Chen
12 PATHOGENESIS OF ACUTE AND CHRONIC HEPATITIS C VIRUS INFECTION 243
Mark A. Feitelson, Helena M.G.P.V. Reis, Jingbo Pan, and Bill Sun
13 MOLECULAR MECHANISMS OF HEPATITIS C VIRUS-INDUCED CELLULAR TRANSFORMATION 267
Donna Sir and Jing-Hsiung James Ou
14 CLINICAL ASPECTS OF HTLV-1-ASSOCIATED CANCER 279
Masao Matsuoka
15 ONCOGENIC POTENTIAL OF THE HTLV-1 TAX PROTEIN 295
Susan J. Marriott
16 HIV-1-ASSOCIATED MALIGNANCY: BASIC AND CLINICAL ASPECTS 317
Melissa Agsalda and Bruce Shiramizu
17 HIV-RELATED LYMPHOMA 337
Giulia De Falco, Cristiana Bellan, Stefano Lazzi, and Lorenzo Leoncini
18 BIOLOGY AND EPIDEMIOLOGY OF HHV-8 351
Veenu Minhas and Charles Wood
19 THE ROLE OF KSHV IN PATHOGENESIS OF KAPOSI'S SARCOMA 377
Gary S. Hayward, Donald J. Alcendor, and Ravit Arav-Boger
20 MOLECULAR PATHOBIOLOGY OF EBV INFECTION 409
Joseph S. Pagano
21 EPSTEIN-BARR VIRUS AS A PATHOGEN 425
Wasim A. Dar and Bill Sugden
Index 453