Kessel / Ben-Tal Introduction to Proteins

Structure, Function, and Motion, Second Edition
2. Auflage 2018
ISBN: 978-1-4987-4721-9
Verlag: CRC Press
Format: EPUB
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 988 Seiten

Reihe: Chapman & Hall/CRC Mathematical and Computational Biology

Introduction to Proteins provides acomprehensiveand state-of-the-art introduction to the structure, function, and motion of proteins for students, faculty, and researchers at all levels.The book coversproteins and enzymesacross a wide range ofcontexts and applications, including medical disorders, drugs, toxins, chemical warfare, and animal behavior. Each chapter includes a Summary, Exercies, and References.
New features in the thoroughly-updated second edition include:

A brand-new chapter on enzymatic catalysis, describing enzyme biochemistry, classification, kinetics, thermodynamics, mechanisms, and applications in medicine and other industries. These are accompanied by multiple animations of biochemical reactions and mechanisms, accessible via embedded QR codes (which can be viewed by smartphones)

An in-depth discussion of G-protein-coupled receptors (GPCRs)

A wider-scale description of biochemical and biophysical methods for studying proteins, including fully accessible internet-based resources, such as databases and algorithms

Animations of protein dynamics and conformational changes, accessible via embedded QR codes

Additional features

Extensive discussion of the energetics of protein folding, stability and interactions

A comprehensive view of membrane proteins, with emphasis on structure-function relationship

Coverage of intrinsically unstructured proteins, providing a complete, realistic view of the proteome and its underlying functions

Exploration of industrial applications of protein engineering and rational drug design

Each chapter includes a Summary, Exercies, and References

Approximately 300 color images

Downloadable solutions manual available at www.crcpress.com
For more information, including all presentations, tables, animations, and exercises, as well asa complete teaching course on proteins' structure and function, please visit the author's website: http://ibis.tau.ac.il/wiki/nir_bental/index.php/Introduction_to_Proteins_Book.

Praise for the first edition
"This book captures, in a very accessible way, a growing body of literature on the structure, function and motion of proteins. This is a superb publication that would be very useful to undergraduates, graduate students, postdoctoral researchers, and instructors involved in structural biology or biophysics courses or in research on protein structure-function relationships." --David Sheehan, ChemBioChem, 2011
"Introduction to Proteins is an excellent, state-of-the-art choice for students, faculty, or researchers needing a monograph on protein structure. This is an immensely informative, thoroughly researched, up-to-date text, with broad coverage and remarkable depth. Introduction to Proteins would provide an excellent basis for an upper-level or graduate course on protein structure, and a valuable addition to the libraries of professionals interested in this centrally important field." --Eric Martz, Biochemistry and Molecular Biology Education, 2012

Autoren/Hrsg.

Kessel, Amit

Ben-Tal, Nir

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Biochemie (med.)
• Mathematik | Informatik EDV | Informatik Programmierung | Softwareentwicklung Spiele-Programmierung, Rendering, Animation

Inhaltsverzeichnis

List of Figures
List of Tables
List of Boxes
Preface
Changes in Second Edition
Physical Quantities and Constants
List of Acronyms

Introduction

Protein Structure

Methods of Structure Determination and Prediction

Energetics and Protein Stability

Protein Dynamics

Intrinsically Unstructured Proteins

Membrane-Bound Proteins

Protein-Ligand Interactions

Enzymatic Catalysis

Über Autor(innen)

Dr. Amit Kessel co-founded and headed the R&D department ofES-IS Technologies, which designs novel enzymatic solutions for the pharmaceutical industry. He studied and trained at Tel-Aviv University and Columbia University, andis currently involved in several academic and industrial biotech initiatives, focusing on experimentally-guided protein structure prediction and on the in-vitro construction of protein-based nanoparticles.
Professor Nir Ben-Tal is based inthe Department of Biochemistry and Molecular Biology at Tel Aviv University. His lab has predicted the 3-D structures ofnumerous transmembrane proteins, providing molecular insight into their mechanisms, and has alsodeveloped the ConSurf web-server for the detection of functional regions by mapping evolutionary data onto protein structures (jointly with the Mayrose and Pupko labs). He studied and trained at the Hebrew University, the Technion, Israel Institute of Technology, and Columbia University.