A Pharmacology Primer

Techniques for More Effective and Strategic Drug Discovery
4th Revised Auflage
ISBN: 978-0-12-407663-1
Verlag: Elsevier Science

Buch, Englisch, 450 Seiten, Format (B × H): 219 mm x 287 mm, Gewicht: 1501 g

A Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery, 4th Edition features the latest ideas and research about the application of pharmacology to the process of drug discovery to equip readers with a deeper understanding of the complex and rapid changes in this field. Written by well-respected pharmacologist, Terry P. Kenakin, this primer is an indispensable resource for all those involved in drug discovery. This edition has been thoroughly revised to include material on data-driven drug discovery, biased signaling, structure-based drug design, drug activity screening, drug development (including pharmacokinetics and safety Pharmacology), and much more. With more color illustrations, examples, and exercises throughout, this book remains a top reference for all industry and academic scientists and students directly involved in drug discovery, or pharmacologic research.

Zielgruppe

<p>Industry, academic and regulatory scientists involved in drug discovery or pharmacologic research, medicinal chemists and industrial chemists</p>

Autoren/Hrsg.

Kenakin, Terry P

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Pharmazie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie

Inhaltsverzeichnis

Chapter 1 - What is Pharmacology?Chapter 2 - How Different Tissues Process Drug ResponseChapter 3 - Drug Receptor TheoryChapter 4 - Pharmacological Assay Formats: BindingChapter 5 - Agonists: The Measurement of Affinity and Efficacy in Functional AssaysChapter 6 - Orthosteric Drug AntagonismChapter 7 - Allosteric Drug InteractionsChapter 8 - Drug DiscoveryChapter 9 - Drug Development: Pharmacokinetics and Safety PharmacologyChapter 10 - Target-and System-based Strategies for Drug DiscoveryChapter 11 - Lead Optimization: Data-Driven AnalysisChapter 12 - Statistics and Experimental DesignChapter 13 - Selected Pharmacological MethodsChapter 14 - Exercises in Pharmacodynamics and PharmacokineticsGlossary of Pharmacological TermsAppendicesStatistical TablesMathematical Fitting Functions

Über Autor(innen)

Kenakin, Terry P
Dr. Terry Kenakin is Professor of Pharmacology at the University of North Carolina School of Medicine. Prior to this, he spent 7 years in drug discovery at Burroughs-Wellcome. He then moved to GlaxoSmithKline for 25 years. Dr. Kenakin has written 11 books on Pharmacology, is the Editor in Chief of the Journal of Receptors and Signal Transduction, is on numerous Editorial Boards. He is the Editor-in-Chief of Comprehensive Pharmacology (Elsevier, 2022). He is the recipient of the 2008 Poulsson Medal for Pharmacology awarded by the Norwegian Society of Pharmacology for achievements in basic and clinical pharmacology and toxicology. He has also been awarded the 2011 Ariens Award from the Dutch Pharmacological Society and the 2014 Gaddum Memorial Award from the British Pharmacological Society, and the 2020 Goodman and Gilman Award in Receptor Pharmacology from ASPET.