Buch, Englisch, 697 Seiten, Previously published in hardcover, Format (B × H): 210 mm x 279 mm, Gewicht: 1713 g
Volume 1: Promising Cancer Chemopreventive Agents
Buch, Englisch, 697 Seiten, Previously published in hardcover, Format (B × H): 210 mm x 279 mm, Gewicht: 1713 g
Reihe: Cancer Drug Discovery and Development
ISBN: 978-1-61737-342-8
Verlag: Humana Press
A comprehensive reference survey on the identification and development of promising cancer chemopreventive agents that will help stimulate further novel research and new approvable drugs. For each agent, the authors review the relevant mechanisms of action, the criteria for populations benefiting from intervention, the safety and pharmacodynamics, clinical study design emphasizing the use of precancers, and early associated cellular and molecular biomarkers of carcinogenesis. The pharmacologic and/or mechanistic classes discussed range from antimutagens, antiinflammatories, and the nuclear receptor superfamily, to signal transduction modulators, antioxidants, vitamins, and minerals. The overall focus is on molecular targets and mechanisms. A second volume, Strategies in Chemoprevention, describes the exciting methodologies that will accelerate progress in this field and discusses the state of clinical development of chemoprevention in the various human cancer target organs.
Zielgruppe
Research
Autoren/Hrsg.
Fachgebiete
- Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Onkologie, Krebsforschung
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
Weitere Infos & Material
I. Antimutagens.- 1 Inducers of Enzymes That Protect Against Carcinogens and Oxidants: Drug- and Food-Based Approaches with Dithiolethiones and Sulforaphane.- 2 Chemoprevention by Isothiocyanates.- 3 Antigenotoxic and Cancer Preventive Mechanisms of N-Acetyl-l-Cysteine.- 4 Modifiers of Cytochrome(s) P450.- II. Antiinflammatories.- 5 Antiinflammatories and Chemoprevention: NSAIDs and Other Inhibitors of Arachidonic Acid Metabolism.- 6 Cyclooxygenase-2 Inhibitors and Colorectal Cancer Prevention.- 7 Lipoxygenases as Targets for Cancer Prevention.- 8 Inducible Nitric Oxide Synthase as a Target for Chemoprevention.- 9 Chemoprevention of Cancer of the Respiratory Tract by Agents Delivered by Aerosol: Applications to Glucocorticoids and 5-Fluorouracil.- 10 Chemoprevention of Cancer by Curcumin.- 11 Prostacyclin and Lung Cancer Chemoprevention.- III. Nuclear Receptor Superfamily.- 12 Nuclear Receptor Superfamily: Targets for Chemoprevention.- 13 Prostate Cancer Chemoprevention: S?-Reductase Inhibitors.- 14 Searching for SARA: The Role of Selective Androgen-Receptor Antagonists in Prostate Cancer.- 15 Aromatase Inhibitors as Chemopreventives of Breast Cancer.- 16 Breast Cancer Chemoprevention by Selective Estrogen Receptor Modulators.- 17 Chemopreventive Efficacy of Natural Vitamin D and Synthetic Analogs.- 18 The Retinoids and Cancer Chemoprevention.- 19 Biologic and Therapeutic Effects of Dehydroepiandrosterone and Structural Analogs.- IV. Signal Transduction Modulators.- 20 ras Oncogene Inhibitors.- 21 The Potential of EGFR-Targeted Agents in Cancer Prevention.- 22 Pharmacological Intervention with Multistep Oncogenesis: Potential Role for HSP90 Molecular Chaperone Inhibitors.- 23 Therapeutic Strategies Targeting Polyamines.- 24 The Role of Phytoestrogens as CancerPrevention Agents.- 25 Cancer Chemopreventive Activity of Monoterpenes and Other Isoprenoids.- 26 Development of an Inhibitor of raf Kinase.- 27 Abnormalities in Cell Cycle Control in Human Cancer and Their Relevance to Chemoprevention.- 28 Select Cyclic Nucleotide Phosphodiesterase Inhibitors in Colon Tumor Chemoprevention and Chemotherapy.- V. Antioxidants, Vitamins, and Minerals.- 29 Chemoprevention by Fruit Phenolic Compounds.- 30 Tea Polyphenols as Cancer Chemopreventive Agents.- 31 Vitamin E as a Cancer Chemopreventive Agent.- 32 Vitamin C as a Cancer Chemopreventive Agent.- 33 Carotenoids.- 34 Lycopene, a Dietary Cancer Chemopreventive Agent.- 35 Not All Chemopreventive Selenium Compounds are Created Equal.- 36 Calcium.- 37 Folate and Cancer Chemoprevention.- 38 Conjugated Linoleic Acid as a Tumor Preventive Agent.- 39 Chemopreventive Effects of Omega-3 Fatty Acids.- VI. Agents Targeting Biological Processes Important in Cancer.- 40 Tumor Angiogenesis as a Target for Early Intervention and Cancer Prevention.- 41 Proteasome Inhibitors in Cancer Therapy.- 42 Modulation of DNA Methylation for the Treatment and Prevention of Cancer.- 43 Targeting Histone Deacetylase as a Strategy for Cancer Prevention.
