Kelloff / Hawk / Sigman Cancer Chemoprevention

Volume 1: Promising Cancer Chemopreventive Agents
Erscheinungsjahr 2004
ISBN: 978-1-59259-767-3
Verlag: Humana Press
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 697 Seiten, eBook

Reihe: Cancer Drug Discovery and Development

Zielgruppe

Research

Autoren/Hrsg.

Kelloff, Gary J.

Hawk, Ernest T.

Sigman, Caroline C.

Inhaltsverzeichnis

I. Antimutagens.- 1 Inducers of Enzymes That Protect Against Carcinogens and Oxidants: Drug- and Food-Based Approaches with Dithiolethiones and Sulforaphane.- 2 Chemoprevention by Isothiocyanates.- 3 Antigenotoxic and Cancer Preventive Mechanisms of N-Acetyl-l-Cysteine.- 4 Modifiers of Cytochrome(s) P450.- II. Antiinflammatories.- 5 Antiinflammatories and Chemoprevention: NSAIDs and Other Inhibitors of Arachidonic Acid Metabolism.- 6 Cyclooxygenase-2 Inhibitors and Colorectal Cancer Prevention.- 7 Lipoxygenases as Targets for Cancer Prevention.- 8 Inducible Nitric Oxide Synthase as a Target for Chemoprevention.- 9 Chemoprevention of Cancer of the Respiratory Tract by Agents Delivered by Aerosol: Applications to Glucocorticoids and 5-Fluorouracil.- 10 Chemoprevention of Cancer by Curcumin.- 11 Prostacyclin and Lung Cancer Chemoprevention.- III. Nuclear Receptor Superfamily.- 12 Nuclear Receptor Superfamily: Targets for Chemoprevention.- 13 Prostate Cancer Chemoprevention: S?-Reductase Inhibitors.- 14 Searching for SARA: The Role of Selective Androgen-Receptor Antagonists in Prostate Cancer.- 15 Aromatase Inhibitors as Chemopreventives of Breast Cancer.- 16 Breast Cancer Chemoprevention by Selective Estrogen Receptor Modulators.- 17 Chemopreventive Efficacy of Natural Vitamin D and Synthetic Analogs.- 18 The Retinoids and Cancer Chemoprevention.- 19 Biologic and Therapeutic Effects of Dehydroepiandrosterone and Structural Analogs.- IV. Signal Transduction Modulators.- 20 ras Oncogene Inhibitors.- 21 The Potential of EGFR-Targeted Agents in Cancer Prevention.- 22 Pharmacological Intervention with Multistep Oncogenesis: Potential Role for HSP90 Molecular Chaperone Inhibitors.- 23 Therapeutic Strategies Targeting Polyamines.- 24 The Role of Phytoestrogens as CancerPrevention Agents.- 25 Cancer Chemopreventive Activity of Monoterpenes and Other Isoprenoids.- 26 Development of an Inhibitor of raf Kinase.- 27 Abnormalities in Cell Cycle Control in Human Cancer and Their Relevance to Chemoprevention.- 28 Select Cyclic Nucleotide Phosphodiesterase Inhibitors in Colon Tumor Chemoprevention and Chemotherapy.- V. Antioxidants, Vitamins, and Minerals.- 29 Chemoprevention by Fruit Phenolic Compounds.- 30 Tea Polyphenols as Cancer Chemopreventive Agents.- 31 Vitamin E as a Cancer Chemopreventive Agent.- 32 Vitamin C as a Cancer Chemopreventive Agent.- 33 Carotenoids.- 34 Lycopene, a Dietary Cancer Chemopreventive Agent.- 35 Not All Chemopreventive Selenium Compounds are Created Equal.- 36 Calcium.- 37 Folate and Cancer Chemoprevention.- 38 Conjugated Linoleic Acid as a Tumor Preventive Agent.- 39 Chemopreventive Effects of Omega-3 Fatty Acids.- VI. Agents Targeting Biological Processes Important in Cancer.- 40 Tumor Angiogenesis as a Target for Early Intervention and Cancer Prevention.- 41 Proteasome Inhibitors in Cancer Therapy.- 42 Modulation of DNA Methylation for the Treatment and Prevention of Cancer.- 43 Targeting Histone Deacetylase as a Strategy for Cancer Prevention.