Kanchi / Sagrado / Sabela Capillary Electrophoresis

Trends and Developments in Pharmaceutical Research
Erscheinungsjahr 2017
ISBN: 978-1-351-84673-8
Verlag: Taylor & Francis
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 410 Seiten

Capillary electrophoresis (CE) has recently become an established method with widespread recognition as an analytical technique of choice in numerous analytical laboratories, including industrial and academic sectors. Pharmaceutical and biochemical research and quality control are the most important CE applications. This book describes recent developments in and applications of CE that are related to (i) compounds of pharmaceutical interest (e.g., drugs, natural products, metabolites, impurities in formulations); (ii) pharmaceutical applications in quality control, drug monitoring, drug interactions, drug metabolism, estimation of physicochemical properties, etc.; and (iii) method development, which includes sample preparation (e.g., in-capillary preconcentration techniques), capillary coating, stationary phases, (enantio)separations (e.g., design of experiments, chiral selectors), and miniaturization.

The book also describes new trends in these areas. It introduces the fundamentals of CE and is aimed at beginners in this field. It clearly outlines the procedures used to mitigate several barriers, such as detection limits, signal detection, changing capillary environment, resolution separation of analytes, and hyphenation of mass spectrometry with CE, for a range of analytical problems. Each chapter outlines a specific electrophoretic variant with detailed instructions and some standard operating procedures. Where necessary, the authors summarize the reported works in tables. All in all, this book provides a comparative assessment of related techniques on mode selection, method development, detection, and quantitative analysis and estimation of pharmacokinetic parameters and broadens the understanding of modern CE applications, developments, and future prospects. In that respect, the book meets its desired goal of rendering assistance to lovers of electrophoresis.

Most books on CE appear to be quite general and include fundamentals, instrumentation, and methods, while some are more specific, covering certain aspects in biochemical or clinical areas. The authors have narrowed their focus and explored CE applications of pharmaceutical interest that are not covered in other books.

Autoren/Hrsg.

Kanchi, Suvardhan

Sagrado, Salvador

Sabela, Myalo I.

Bisetty, Krishna

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Naturwissenschaften Chemie Analytische Chemie
• Naturwissenschaften Chemie Physikalische Chemie

Inhaltsverzeichnis

Capillary Electrophoresis: A Versatile Technique in Pharmaceutical Analysis

Imran Ali, Zeid A. AL-Othman, Abdulrahman Alwarthan, and Hassan Y. Aboul-Enein

Recent Applications of Chiral Capillary Electrophoresis in Pharmaceutical Analysis

J. M. Saz and M. L. Marina

A Mini Review on Enantiomeric Separation of Ofloxacin Using Capillary Electrophoresis: Pharmaceutical Applications

S Kanchi, M I. Sabela, D. Sharma, and K. Bisetty

Nano-stationary Phases for Capillary Electrophoresis Techniques

Chaudhery Mustansar Hussain and Sagar Roy

Capillary Electrophoresis Coupled to Mass Spectrometry for Enantiomeric Drugs Analysis

Vítezslav Maier, Martin Švidrnoch, and Jan Petr

Enantioselective Drug–Plasma Protein Binding Studies by Capillary Electrophoresis

L-Escudert-Gilabert, Y. Martín-Biosca, S. Sagrado, and M.J. Medina-Hernández

Clinical Use of Capillary Zone Electrophoresis: New Insights into Parkinson´s Disease

Pedro Rada

Electrophoretically Mediated Microanalysis for Evaluation of Enantioselective Drug Metabolism

Y. Martín-Biosca, L-Escudert-Gilabert, S. Sagrado, and M.J. Medina-Hernández

Capillary Electrophoresis for the Quality Control of Intact Therapeutic Monoclonal Antibodies

Anne-Lise Mariea, Grégory Roubyb, Emmanuel Jaccouleta, Claire Smadjaa, N. Thuy Trana, and Myriam Tavernaa

Molecular Simulation of Chiral Selector-Enantiomer Interactions through Docking: Antimalarial Drug as a Case Study

M. Sabela, S. Kanchi, D. Sharma, and K. Bisetty

Über Autor(innen)

Suvardhan Kanchi’s research involves the development of methods to separate organic and inorganic molecules from environmental samples using capillary electrophoresis (CE). He is also interested in the fabrication of electrochemical nano-/biosensors for high-intensity artificial sweeteners, bisphenols, and dyes. He has co-authored around 55 papers and book chapters in international peer-reviewed journals.

Salvador Sagrado received a PhD in chemistry from Universitat de València, Spain, in 1988. He is currently full professor in the Department of Analytical Chemistry at Universitat de València and secretary of the IDM Interuniversity Research Institute. His current research focuses on chemometrics and enantioselectivity. He has co-authored around 150 papers and book chapters in international journals.

Myalowenkosi Sabela is currently conducting doctoral research at the Durban University of Technology, South Africa. His research interest is in pharmacokinetic and enantioselective parameters of pharmaceutical compounds in the presence of biomacromolecules and nanoparticles for applications such as diagnostics and sensors. His research interest earned him the 2014–2015 Erasmus Mundus-EUROSA fellowship, among others, and he has published 28 papers.

Krishna Bisetty received his PhD in chemistry from the University of KwaZulu-Natal, South Africa, in 2002. He is head of the Department of Chemistry at the Durban University of Technology, South Africa. His research is largely based on high-performance computing (HPC), ranging from small organic molecules to bioactive macromolecules, including the development of computational models for designing more effective host–guest systems using state-of-the-art molecular dynamics and docking simulations supported by experimental studies. As an established NRF C3 researcher, Dr. Bisetty has published more than 90 research papers in peer-reviewed journals and 4 book chapters.