High Throughput Screening for Novel Anti-Inflammatories

Erscheinungsjahr 2012
ISBN: 978-3-0348-9578-1
Verlag: Birkhäuser

Buch, Englisch, 258 Seiten, Format (B × H): 155 mm x 235 mm, Gewicht: 417 g

Reihe: Progress in Inflammation Research

Combinatorial chemistry in conjunction with High Throughput Screening

(HTS) is revolutionizing the drug discovery process. Yet, we have much

to learn about the integration of these powerful techniques with

information from genomics, proteomics, computation and pharmacokinetics

before dramatic increases in the drug discovery/development processes

can be achieved. The chapters in this book represent the state of the

art regarding the integration of combinatorial chemistry and HTS in

connection with anti-inflammatory targets. Obviously, there is much work

to be done beyond what is described in this text, nevertheless, it

should set the stage for creative thinking among scientists of many

disciplines for the accomplishment of our ultimate goals in treating

inflammatory diseases.

Zielgruppe

Professional/practitioner

Autoren/Hrsg.

Kahn, Michael

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Biomedizin, Medizinische Forschung, Klinische Studien

Inhaltsverzeichnis

Contents. List of Contributors. Intoduction. Sharon M. Dankwardt: Solid phase synthesis: applications to combinatorial libraries. Mohamed A. Iqbal and Mark A. Ator: Proteaspme inhibitors. Tariq Ghayur, Sheryl J. Hays and Robert V. Talanian: Caspase-1 (ICE) and other caspases as drug discovery targets: opportunities and progress. William A. Metz and Norton P. Peet: Elastase inhibitors. M. Anthony Leesnitzer, D. Mark Bickett, Marcia L. Moss and J. David Becherer: A high-throughput assay for the TNF conerting enzyme. Kenneth D. Rice and William R. Moore: Tryptase inhibitors. Falguni Dasgupta: Selectin antagonists. Kerry W. Fowler and David T. Crowe: Cell adhesion integrins as pharmaceutical targets. Brion W. Murray, Yoshitaka Satoh and Bernd Stein: Inhibitors of the MAPK pathway. Mark J. Suto and Anthony M. Manning: Inhibition of NF-kB. Terry L. Bowlin, Stephen D. Yanofsky and Herman Schreuder: IL-1 antagonist discovery. Mark A. Giembycz: Phosphodiesterase inhibitors for respiratory disease. Subject index