Iuchi / Kuldell Zinc Finger Proteins

From Atomic Contact to Cellular Function
1. Auflage 2007
ISBN: 978-0-387-27421-8
Verlag: Springer US
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 276 Seiten

Reihe: Molecular Biology Intelligence Unit

In the early 1980s, a few scientists started working on a Xenopus transcription factor, TFIIIA. They soon discovered a novel domain associated with zinc, and named this domain 'zinc finger. ' Th e number of proteins with similar zinc fingers grew quickly and these proteins are now called C2H2, Cys2His2 or classical zinc finger proteins. To date, about 24,000 C2H2 zinc finger proteins have been recognized. Approximately 700 human genes, or more than 2% of the genome, have been estimated to encode C2H2 finger proteins. From the beginning these proteins were thought to be numerous, but no one could have predicted such a huge number. Perhaps thousands of scientists are now working on C2H2 zinc finger proteins fi-om variou s viewpoints. This field is a good example of how a new science begins with the insight of a few scientists and how it develops by efforts of numerous independent scientists, in contrast to a policy-driven scientific project, such as the Human Genome Project, with goals clearly set at its inception and with work performed by a huge collaboration throughout the world. As more zinc finger proteins were discovered, several subfamilies, such as C2C2, CCHC, CCCH, LIM, RING, TAZ, and FYVE emerged, increasing our understanding of zinc fingers. The knowledge was overwhelming. Moreover, scientists began defining the term 'zinc finger' differently and using various names for identical zinc fingers. These complications may explain why no single comprehensive resource of zinc finger proteins was available before this publication.

Autoren/Hrsg.

Iuchi, S.

Kuldell, N.

Iuchi, Shiro

Kuldell, Natalie

Inhaltsverzeichnis

1;CONTENTS;5
2;EDITORS;7
3;CONTRIBUTORS;7
4;PREFACE;13
5;ABBREVIATIONS;14
6;The Discovery of Zinc Fingers and Their Practical Applications in Gene Regulation: A Personal Account;17
7;C2H2 Zinc Fingers As DNA Binding Domains;23
8;TFIIIA: A Sophisticated Zinc Finger Protein;30
9;GAGA: Structural Basis for Single Cys2 His2 Zinc Finger- DNA Interaction;36
10;The DNA- Binding Domain of GATA Transcription Factors— A Prototypical Type IV Cys2 - Cys2 Zinc Finger;42
11;MutM: Single C2 C2 Zinc Finger- DNA Interaction;47
12;Homing Endonuclease I- TevI: An Atypical Zinc Finger with a Novel Function;51
13;Zinc Finger Interactions with Metals and Other Small Molecules;55
14;Synthetic Zinc Finger Transcription Factors;63
15;THIIA and p43: Binding to 5S Ribosomal RNA;72
16;RNA Binding by Single Zinc Fingers;82
17;Wig- 1, a p53- Induced Zinc Fineer Protein that Binds Double Stranded RNA;92
18;Tandem CCCH Zinc Finger Proteins in mRNA Binding;96
19;Ribosomal Zinc Finger Proteins: The Structure and the Function of Yeast YL37a;107
20;LIM Domain and Its Binding to Target Proteins;115
21;RING Finger- B Box- Coiled Coil ( RBCC) Proteins As Ubiquitin Ligase in the Control of Protein Degradation and Gene Regulation;122
22;Structure and Function of the CBP/ p300 TAZ Domains;130
23;A Zinc Ribbon Motif Is Essential for the Formation of Functional Tetrameric Protein Kinase CK2;137
24;The FYVE Finger: A Phosphoinositide Binding Domain;144
25;The BTB Domain Zinc Finger Proteins;150
26;KRAB Zinc Finger Proteins: A Family of Repressors Mediating Heterochromatin- Associated Gene Silencing;167
27;The Superfamily of SCAN Domain Containing Zinc Finger Transcription Factors;172
28;Spl and Huntington's Disease;184
29;The Role of WTl in Development and Disease;190
30;Yin Yang 1;198
31;The Multiple Cellular Functions of TFIIIA;211
32;The Role of the Ikaros Gene Family in Lymphocyte Development;216
33;Basonuclin: A Zinc Finger Protein of Epithelial Cells and Reprocmctive Germ Cells;223
34;ZAS Zinc Fineer Proteins: The Other KB- Binding Protein Family;229
35;Role of GATA Factors in Development;237
36;The Androgen Receptor and Spinal and Bulbar Muscular Atrophy;248
37;The Role of XPA in DNA Repair;255
38;MOF, an Acetyl Transferase Involved in Dosage Compensation in Drosophila^ Uses a CCHC Finger for Substrate Recognition;263
39;MDM2: RING Finger Protein and Regulator of p53;268
40;The Zip Family of Zinc Transporters;277
41;Apoptosis by Zinc Deficiency;281
42;INDEX;288