Bioinformatics of Autoimmune Diseases

1. Auflage 2026
ISBN: 978-1-041-16611-5
Verlag: CRC Press

Buch, Englisch, 384 Seiten, Format (B × H): 178 mm x 254 mm

Reihe: Chapman & Hall/CRC Computational Biology Series

Autoimmune diseases arise when the immune system misidentifies the body’s own tissues as threats, a catastrophic failure of self-recognition that leads to chronic inflammation, tissue damage, and long-term disability. Bioinformatics of Autoimmune Diseases is a timely and comprehensive guide that explores not only the immunological basis of these disorders but also the cutting-edge bioinformatics approaches used to analyze the genomic, transcriptomic, and epigenomic data driving modern discovery.

Structured to bridge foundational immunology with advanced computational analysis, this book offers readers a progression from the molecular mechanisms of immune function and dysfunction to the bioinformatics pipelines used to investigate them. Early chapters provide a thorough grounding in immune cell biology, immune checkpoints, and disease pathogenesis. Subsequent chapters guide readers through practical analyses of autoimmune disease data, covering RNA-Seq, variant analysis, microbiome profiling, ATAC-Seq, ChIP-Seq, and single-cell sequencing. Bioinformatics tools are introduced using Python with step-by-step workflows, enabling hands-on engagement with real datasets.

Written by a professor of bioinformatics and developer of bioinformatics tools, the book draws from over a decade of broad experience in computational biology. With detailed illustrations, curated datasets, and a clear emphasis on reproducibility, it serves as a foundational resource for graduate students, clinician, biomedical researchers, and anyone seeking to decode the bioinformatic foundations and mechanisms driving autoimmune disease.

Zielgruppe

Academic, Postgraduate, Professional Practice & Development, and Undergraduate Advanced

Autoren/Hrsg.

Ismail, Hamid D

Fachgebiete

• Naturwissenschaften Biowissenschaften Molekularbiologie
• Naturwissenschaften Biowissenschaften Biowissenschaften Genetik und Genomik (nichtmedizinisch)
• Naturwissenschaften Biowissenschaften Angewandte Biologie Bioinformatik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Medizin, Gesundheit: Sachbuch, Ratgeber
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Immunologie
• Mathematik | Informatik EDV | Informatik Angewandte Informatik Bioinformatik
• Naturwissenschaften Chemie Chemie Allgemein Chemometrik, Chemoinformatik

Inhaltsverzeichnis

Ch 1 Immune Mechanisms and Major Autoimmune Diseases Ch 2 Genetic Markers in Autoimmunity Ch 3 Bioinformatics Design for Autoimmune Research Ch 4 Bioinformatics Databases Ch 5 RNA Sequencing Ch 6 Variant Analysis Ch 7 DNA-Protein Interactions and Autoimmune Diseases Ch 8 ATAC-Seq for Autoimmune Diseases Ch 9 Roles of Bacteria in Autoimmune Diseases Ch 10 Gene Therapy and Autoimmune Diseases Index

Über Autor(innen)

Hamid Ismail is a professor of bioinformatics and an HPC center administrator. His research bridges biology and computation, focusing on bioinformatics tools, disease genomics, and machine learning. He is the author of several acclaimed textbooks that advance education and research in computational biology and genomics.