Cytochromes P450

1. Auflage 2019
ISBN: 978-0-367-24352-4
Verlag: Taylor and Francis

Buch, Englisch, 411 Seiten, Format (B × H): 178 mm x 254 mm, Gewicht: 920 g

Reihe: Routledge Revivals

First published in 1996: An in-depth book on the role of cytochrome P450 proteins from a toxicological perspective, Cytochromes P450: Metabolics and Toxicological Aspects examines the proteins and their role in toxicity/carcinogenicity and the metabolism of foreign chemicals.

Zielgruppe

Pharmacological researchersToxicologistsPharmaceutical industries and laboratories

Autoren/Hrsg.

Ioannides, Costas

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Biochemie (med.)
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie

Inhaltsverzeichnis

Part 1: General Considerations
1. Cytochrome P450: From a Single Protein to a Family of Proteins-With Some Personal Reflections
R.W. Estabrook
2. Role of Metabolism in Chemical Toxicity
N.P.E. Vermeulen
3.The Chemistry of Cytochrome P450 Reactions
F.P. Guengerich
Part 2: Cytochrome P450 Families/Subfamilies
4. The CYP1 Family
K. Kawajiri and S. i. Hayashi
5. The CYP2A Subfamily
T.H.K. Chang and D.J. Waxman
6. The CYP2B Subfamily
R.W. Nims and R.A. Lubet
7. The CYP2C Subfamily
T.H. Richardson and E.F. Johnson
8. The CYP2D Subfamily
F.J. Gonzalez
9. The CYP2E Subfamily
M.J.J. Ronis, K.O. Lindros, and M. Ingelman-Sundberg
10. The CYP3A Family
P. Maurel
11. The CYP4 Family
B.G. Lake and D.F.V. Lewis
Part 3: Current Issues
12. Expression of Cytochrome P450 Proteins in Disease
C. Ioannides, C.R. Barnett, A. Irizar, and P.R. Flatt
13. Cytochromes P450 and Immunotoxicity
M. Pirmohamed and B.K. Park
14. Molecular Modeling of Mammalian Cytochromes P450
D.F.V. Lewis

Über Autor(innen)

Costas Ionnides, Ph.D., is Senior Research Fellow in toxicology in the School of Biological Sciences at the University of Surrey in Guildford, England.