Buch, Englisch, 150 Seiten, Format (B × H): 175 mm x 250 mm, Gewicht: 450 g
Reihe: Annals of the ICRP
Low-Dose Extrapolation of Radiation-related Cancer Risk
Buch, Englisch, 150 Seiten, Format (B × H): 175 mm x 250 mm, Gewicht: 450 g
Reihe: Annals of the ICRP
ISBN: 978-0-08-044958-6
Verlag: SAGE Publications Ltd
This report considers the evidence relating to cancer risk associated with exposure to low doses of low linear energy transfer radiation, and particularly doses below current recommended limits for protection of radiation workers and the general public. The focus is on evidence regarding linearity of the dose–response relationship for all cancers considered as a group, but not necessarily individually, at low doses [the so-called linear, non-threshold (LNT) hypothesis]. It looks at the possibility of establishing a universal threshold dose below which there is no risk of radiation-related cancer. The report is organised by scientific discipline, beginning with epidemiological studies of exposed human populations.
Autoren/Hrsg.
Fachgebiete
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Präventivmedizin, Gesundheitsförderung, Medizinisches Screening
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Public Health, Gesundheitsmanagement, Gesundheitsökonomie, Gesundheitspolitik
Weitere Infos & Material
ABSTRACT
GUEST EDITORIAL
PREFACE
EXECUTIVE SUMMARY
INTRODUCTION
EPIDEMIOLOGICAL CONSIDERATION
Introduction
Inferences based on acute doses in the moderate-to-high dose range
Estimation of risk at low doses and low dose rates
Thresholds vs. the linear, no-threshold theory
Conclusion: Implications for low-dose cancer risk
LOW-DOSE RISK - BIOLOGY
Introduction
Damage caused by radiation
Damage Response Pathways
Fidelity of DSB repair
Impact of defects in DNA repair, checkpoint control and apoptosis
Conclusions
CELLULAR CONSEQUENCES OF RADIATION-INDUCED DAMAGE
Radiation- induced Chromosome Aberrations
Radiation-Induced Somatic Cell Mutations
Adaptive Response, Genomic Instability and Bystander Effect
Conclusions: Implications for Risk Assessment
CARCINOGENIC EFFECTS OF IONIZING RADIATION
Mechanisms of radiation-induced cancer
Tissue Modifying Factors
Radiation-induced Cancer in Animals
Life Shortening
Summary
Conclusions: Implications for radiation-related cancer at low doses
QUANTITATIVE UNCERTAINTY ANALYSIS
Overview
Sources of uncertainty
Allowing for the uncertain possibility of a threshold
Conclusions
CONCLUSIONS
REFERENCES
