ICRP Publication 90

1. Auflage 2003
ISBN: 978-0-08-044265-5
Verlag: SAGE Publications Ltd

Buch, Englisch, 206 Seiten, Format (B × H): 170 mm x 244 mm, Gewicht: 1000 g

Reihe: Annals of the ICRP

In its 1990 recommendations, the ICRP considered the radiation risks after exposure during prenatal development. This report is a critical review of new experimental animal data on biological effects and evaluations of human studies after prenatal radiation published since the 1990 recommendations. Thus, the report discusses the effects after radiation exposure during pre-implantation, organogenesis, and fetogenesis. The aetiology of long-term effects on brain development is discussed, as well as evidence from studies in man on the effects of in-utero radiation exposure on neurological and mental processes. Animal studies of carcinogenic risk from in-utero radiation and the epidemiology of childhood cancer are discussed, and the carcinogenic risk to man from in-utero radiation is assessed. Open questions and needs for future research are elaborated. The report reiterates that the mammalian embryo and fetus are highly radiosensitive. The nature and sensitivity of induced biological effects depend upon dose and developmental stage at irradiation. The various effects, as studied in experimental systems and in man, are discussed in detail. It is concluded that the findings in the report strengthen and supplement the 1990 recommendations of the ICRP.

Autoren/Hrsg.

Icrp

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Public Health, Gesundheitsmanagement, Gesundheitsökonomie, Gesundheitspolitik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Präventivmedizin, Gesundheitsförderung, Medizinisches Screening

Inhaltsverzeichnis

Preface

Introduction

1. Radiation effects after exposure during the pre-implantation period

2. Developmental Effects after Irradiation during organogenesis and fetogenesis

3. Aetiology of long-term effects during brain development

4. Human evidence on the effects of in-utero radiation exposure on neurological and mental processes

5. Carcinogenic Risk from In-Utero Irradiation: Animal Studies

6. Epidemiology of Childhood Cancer

7. Human Carcinogenic Risk from In-Utero Irradiation

8. Summary and Conclusions

9. Open Questions and needs of future research