Hudetz / Pearce Suppressing the Mind

Anesthetic Modulation of Memory and Consciousness
1. Auflage 2010
ISBN: 978-1-60761-462-3
Verlag: Humana Press
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 252 Seiten

Reihe: Contemporary Clinical Neuroscience

Anesthetics produce a reversible state of unconsciousness accompanied by ante- grade amnesia. This remarkable phenomenon brings great relief to surgical patients and wonder to clinicians and scientists. To date, we do not fully understand the mechanisms by which anesthetics ablate conscious sensation and memory. We are, however, making progress. This book presents original results as well as overviews of the current state of knowledge of the problem. It is authored by investigators who know the ?eld well; their research at a number of levels has contributed substantially to our c- rent understanding of anesthetic modulation of memory and consciousness. Most of the contributors were presenters at two workshops organized by Dr. Pearce and Dr. Hudetz at the 40th Annual Winter Conference on Brain Research, held at Snowmass Village, Colorado, from January 27 through February 2, 2007. One workshop focused on anesthetic modulation of consciousness and another on an- thetic modulation of memory. Seven of the chapters are based on material presented at these symposia – appropriately updated with new relevant ?ndings. This infor- tion is supplemented by chapters on anesthesia and sleep, computational analysis of the state of anesthesia, and the clinical phenomenon of “anesthesia awareness,” a topic that has recently received much public attention. With these three additional contributions, the book thus includes 10 chapters.

Autoren/Hrsg.

Hudetz, Anthony

Pearce, Robert

Inhaltsverzeichnis

1;Foreword;5
2;Contents;7
3;Contributors;9
4;Introduction;11
5;Molecular Targets of General Anesthetics in the Nervous System;20
6;A Neurochemical Perspective on States of Consciousness;41
7;Anesthetic Modulation of Auditory Perception: Linking Cellular, Circuit, and Behavioral Effects;89
8;Cortical Disintegration Mechanism of Anesthetic- Induced Unconsciousness;106
9;Anesthesia and the Thalamocortical System;133
10;Anesthesia-Induced State Transitions in Neuronal Populations;145
11;Anesthesia Awareness: When the Mind Is Not Suppressed;167
12;Loss of Recall and the Hippocampal Circuit Effects Produced by Anesthetics;180
13;Modulation of the Hippocampal .-Rhythm as a Mechanism for Anesthetic-Induced Amnesia;198
14;Propofol Amnesia – What is Going on in the Brain?;220
15;Subject Index;249