Hu / Li Oral Bioavailability

Basic Principles, Advanced Concepts, and Applications
1. Auflage 2011
ISBN: 978-1-118-06758-1
Verlag: John Wiley & Sons
Format: EPUB
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 560 Seiten, E-Book

Reihe: Wiley series in drug discovery and development

Understand and assess the design, delivery, and efficacy oforally administered drugs
A practical guide to understanding oral bioavailability, one ofthe major hurdles in drug development and delivery, OralBioavailability: Basic Principles, Advanced Concepts, andApplications is designed to help chemists, biologists, life scienceresearchers, pharmaceutical scientists, pharmacologists,clinicians, and graduate and students become familiar with thefundamentals and practices of the science of oralbioavailability.
The difference in rate and extent between a drug taken orallyand the actual amount of a drug reaching the circulatory system,oral bioavailability is an essential parameter for determining theefficacy and adverse effects of new and developing medications, aswell as finding an optimal dosing regimen.
This book provides a much-needed one-stop resource to helpreaders better understand and appreciate the many facets andcomplex problems of oral bioavailability, including the basicbarriers to oral bioavailability, the methods used to determinerelevant parameters, and the challenges of drug delivery.
In addition, this comprehensive book discusses biological andphysicochemical methods for improving bioavailability, integratesphysicochemistry with physiology and molecular biology, andincludes several state-of-the-art technologies andapproaches--Caco-2 cell culture model, MDCK, and other relatedcell culture models--which are used to study the science oforal bioavailability.

Autoren/Hrsg.

Li, Xiaoling

Hu, Ming

Über Autor(innen)

Ming Hu, PhD, is Professor of Pharmaceutics at the College of Pharmacy, University of Houston. Dr. Hu is on the editorial boards of Molecular Pharmaceutics and the Journal of Alternative and Complementary Medicine.
Xiaoling Li, PhD, is Professor of Pharmaceutics and Associate Dean of Graduate Education and Research at the Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific. He is a Fellow of the American Association of Pharmaceutical Scientists.