Buch, Englisch, 624 Seiten, Format (B × H): 174 mm x 246 mm, Gewicht: 1152 g
Buch, Englisch, 624 Seiten, Format (B × H): 174 mm x 246 mm, Gewicht: 1152 g
ISBN: 978-0-367-39831-6
Verlag: Taylor & Francis Ltd
This book integrates recent advances in molecular and cell biology of hematopoietic stem cells (HSC) with developments in clinical research in stem cell-based therapy-providing an up-to-date review of novel cytokines and cellular components; animal models; cell preparation, selection, and collection; minimal residual disease and purging; expansion of progenitor cells; allogeneic and autologous transplantation; cellular gene and immunotherapy; and more.
Examines key areas for treatment with HSC, including ambulatory care and monitoring, regimen-related toxicities, immunodeficiency and immunization, infection, chronic graft-versus-host and disease, secondary malignancies, and long-term quality of life.
Covering stem cell pool regulation and the complex interplay of extrinsic and intrinsic events, Hematopoietic Stem Cell Transplantation
- summarizes current understanding and development of clinical allogeneic HSC transplantation
- discusses the use of allogeneic transplantations with reduced conditioning regimen or mini-transplantation
- considers various strategies for mobilization of HSCs from peripheral blood (PB) of normal donors
- details detection of bone marrow contamination by tumor cells and removal procedures
- focuses on efforts to increase the ex vivo transduction efficiency of human HSCs with retroviral vectors
- explores the effects of growth factor administration and leukapheresis on PB stem cell donors
- shows the impact of CD34+ cell isolation and the relevance of expansion of HSC from bone marrow for clinical use
- reveals how minimal residue disease detection assays are crucial for tracking the clinical significance of infused tumor cells
- employs automated fluorescence image cytometry to study early HSC behavior following seeding
Incorporating contributions from over 90 researchers who cite more than 2180 references to encourage continued study,
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