Buch, Englisch, 270 Seiten, Format (B × H): 155 mm x 235 mm, Gewicht: 435 g
Buch, Englisch, 270 Seiten, Format (B × H): 155 mm x 235 mm, Gewicht: 435 g
Reihe: Progress in Inflammation Research
ISBN: 978-3-0348-9572-9
Verlag: Birkhäuser
Cytokines have become established as key mediators of the signs and
symptoms of inflammatory diseases such as arthritis, dermatitis, asthma
and multiple sclerosis. Furthermore, they are involved in the cascade of
events leading to cardiovascular shock and are major regulators of the
function of immune cells.
This book reviews recent advances in the development of new
anti-inflammatory drugs. It addresses different therapeutic intervention
possibilities for new drugs, such as the cellular source of cytokines,
specific receptors which induce cytokine synthesis, intracellular
regulators of cytokine gene induction and expression, secretion and
activation of cytokines, cytokine receptors and signalling pathways from
these receptors. Accordingly, experts were drawn from different
backgrounds including academic research institutes, the pharmaceutical
industry and clinical pharmacology. In each area, the opportunities for
drug development are highlighted and, where possible, clinical data is
reviewed.
Zielgruppe
Professional/practitioner
Autoren/Hrsg.
Fachgebiete
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Immunologie
- Naturwissenschaften Biowissenschaften Zellbiologie
Weitere Infos & Material
Targets for modulating cytokine responses in inflammatory and infectious diseases.- Cell signaling and cytokine induction by lipopolysaccharide.- Regulation of cytokine production by inhibitors of cell signalling.- Oligonucleotide-based drugs in the control of cytokine synthesis.- Inhibiting cytokine-processing enzymes.- Cytokine-neutralizing therapeutic antibodies.- The debut of anti-TNF therapy of rheumatoid arthritis in the clinic.- Blockade of cytokine activity by soluble cytokine receptors.- Interleukin-1 receptor antagonist.- Therapeutic regulation of cytokine signalling by inhibitors of p38 mitogen-activated protein kinase.- TGF? and IL-10: inhibitory cytokines regulating immunity and the response to infection.- Therapeutic control of cytokines: lessons from microorganisms.
