Buch, Englisch, 448 Seiten, Format (B × H): 178 mm x 254 mm, Gewicht: 988 g
Reihe: Routledge Revivals
Buch, Englisch, 448 Seiten, Format (B × H): 178 mm x 254 mm, Gewicht: 988 g
Reihe: Routledge Revivals
ISBN: 978-0-367-23036-4
Verlag: TAYLOR & FRANCIS
First published in 1991. Historically, phospholipid binding antibodies were important in the study of syphilis. During the 1980s there was a resurgence of new interest in these antibodies due to reported associations with recurrent thrombosis, fetal loss, and other clinical disorders. Because of the variety of reported clinical associations and their occurrence in systemic autoimmune disorders, these antibodies have become important in many medical fields, such as clinical immunology, rheumatology, hematology, and obstetrics and gynecology. Phospholipid-Binding Antibodies provides in-depth reviews by specialists in these clinical areas and covers topics including the biochemistry of phospholipids, their role in coagulation, phospholipid immunology, and lupus anticoagulant and antiphospholipid antibodies by solid phase immunoassays. Other topics include thrombosis and fetal loss, as well as the role of phospholipid binding antibodies in these disorders. Antiphospholipid Syndrome and its reported clinical associations is also discussed.
Autoren/Hrsg.
Fachgebiete
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Rheumatologie, Muskelerkrankungen
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Immunologie
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Gynäkologie, Geburtshilfe
Weitere Infos & Material
SECTION I: PHOSPHOLIPIDS AND CLOTTING. 1. Structures and Properties of Self-Assembles Phospholipids in Excess Water. 2. Phospholipids and the Clotting Process. SECTION II: THE IMMUNOLOGY OF PHOSPHOLIPID-BINDING AUTOANTIBODIES. 3. Autoantibodies: Their Nature and Significance. 4. Antibodies to Lipids and Lipid Membranes: Reactions with Phosphatidylcholine, Cholesterol, Liposomes, and Bromelin-Treated Erythrocytes. 5. Phospholipid Antibodies in Natural and Experimental Syphilis. 6. Role of Monoclonal Antibodies in Understanding the Interactions Between Anti-Phospholipid Antibodies and Phospholipids. 7. The Immunology of Phospholipid-Binding Antibodies in the Anti-Phospholipid Syndrome and Related Disorders. SECTION III: MEASUREMENT OF PHSOPHOLIPID-BINDING ANTIBODIES. 8. Lupus Anticoagulants: Characteristics, Methods of Laboratory Detection and Some Clinical Associations. 9. Acquired Circulating Anticoagulants Other than Lupus Anticoagulants. 10. The Anti-Cardiolipin Assay. SECTION IV: PHOSPHOLIPID-BINDING ANTIBODIES AND THROMBOSIS. 11. Arterial Thrombosis – Diagnosis and Management. 12. Spontaneous (Unexplained) Thrombosis: The Inherited Basis for the Thrombohemorrhagic. 13. The Pathogenic Role of Anti-Phospholipid Antibodies in Thrombosis. 14. Anti-Phospholipid Antibodies and Impairment of Prostacyclin Synthesis. 15. Hematological Immune Cytopenias and Anti-Phospholipid. 16. Anti-Phospholipid Autoantibodies in Thrombosis: Cause and-or Consequence of the Disruption of the Protein C-Dependent Hemostatic Balance. SECTION V: PHOSPHOLIPID-BINDING ANTIBODIES ANTIBODIES AND PREGNANCY LOSS. 17. Habitual Abortion. 18. Pregnancy in SLE. 19. Treatment of Anti-Phospholipid Antibody Mediated Fetal Loss: The Case for Corticosteroid Therapy. 20. Clinical Implications of Anti-Phospholipid Antibodies: The Utah Experience. 21. Alternative Approaches to Treatment of Women with Anti-Phospholipid Antibodies and Fetal Loss. 22. Anti-Phospholipid Antibodies and Fetal-Loss – Proposed Mechanisms. SECTION VI: THE ANTI-PHOSPHOLIPID SYNDROME. 23. The Anti-Phospholipid Syndrome – and Introduction. 24. "Primary" Anti-Phospholipid Syndrome. 25. Anti-Phospholipid Antibodies: Clinical Complications Reported in Medical Literature. 26. Anti-Phospholipid Syndrome in Murine Lupus. 27. Anti-Phospholipid Antibodies: A Personal History. INDEX.
