Protein Conformational Dynamics

2014
ISBN: 978-3-319-02969-6
Verlag: Springer International Publishing

Buch, Englisch, Band 805, 488 Seiten, Format (B × H): 160 mm x 241 mm, Gewicht: 9596 g

Reihe: Advances in Experimental Medicine and Biology

This book discusses how biological molecules exert their function and regulate biological processes, with a clear focus on how conformational dynamics of proteins are critical in this respect. In the last decade, the advancements in computational biology, nuclear magnetic resonance including paramagnetic relaxation enhancement, and fluorescence-based ensemble/single-molecule techniques have shown that biological molecules (proteins, DNAs and RNAs) fluctuate under equilibrium conditions. The conformational and energetic spaces that these fluctuations explore likely contain active conformations that are critical for their function. More interestingly, these fluctuations can respond actively to external cues, which introduces layers of tight regulation on the biological processes that they dictate. A growing number of studies have suggested that conformational dynamics of proteins govern their role in regulating biological functions, examples of this regulation can be found in signal transduction, molecular recognition, apoptosis, protein / ion / other molecules translocation and gene expression.On the experimental side, the technical advances have offered deep insights into the conformational motions of a number of proteins. These studies greatly enrich our knowledge of the interplay between structure and function.On the theoretical side, novel approaches and detailed computational simulations have provided powerful tools in the study of enzyme catalysis, protein / drug design, protein / ion / other molecule translocation and protein folding/aggregation, to name but a few. This work contains detailed information, not only on the conformational motions of biological systems, but also on the potential governing forces of conformational dynamics (transient interactions, chemical and physical origins, thermodynamic properties). New developments in computational simulations will greatly enhance our understanding of how these molecules function invarious biological events.

Zielgruppe

Research

Autoren/Hrsg.

Han, Ke-Li

Yang, Ming-Jun

Zhang, Xin

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Biomedizin, Medizinische Forschung, Klinische Studien
• Naturwissenschaften Biowissenschaften Proteinforschung

Inhaltsverzeichnis

Protein folding simulations by generalized-ensemble algorithms.- Application of Markov State Models to Simulate Long Timescale Dynamics of Biological Macromolecules.- Understanding protein dynamics using conformational ensembles.- Generative Models of Conformational Dynamics.- Generalized spring tensor models for protein fluctuation dynamics and conformation changes.- The Joys and Perils of Flexible Fitting.- Coarse-Grained Models of the Proteins Backbone Conformational Dynamics.- Simulating protein folding in different environmental conditions.- Simulating the peptide folding kinetic related spectra based on the Markov State Model.- The Dilemma of Conformational Dynamics in Enzyme Catalysis: Perspectives from Theory and Experiment.- Exploiting protein intrinsic flexibility in drug design.- NMR and computational methods in the structural and dynamic characterization of ligand-receptor interactions.- Molecular Dynamics Simulation of Membrane Proteins.- Free-energy landscape of intrinsically disordered proteins investigated by all-atom multicanonical molecular dynamics.- Coordination and control inside simple biomolecular machines.- Multi-state Targeting Machinery Govern the Fidelity and Efficiency of Protein Localization.- Molecular dynamics simulations of F1-ATPase.- Chemosensorial G-proteins-coupled receptors: a perspective from computational methods.