Haga / Takeda G Protein-Coupled Receptors

Structure, Function, and Ligand Screening
Erscheinungsjahr 2010
ISBN: 978-1-4200-3827-9
Verlag: Taylor & Francis
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 336 Seiten

Reihe: Methods in Signal Transduction Series

This book provides a broad base of knowledge of G-protein-coupled receptors. Useful at both the university and industrial levels, this book is of particular interest to those who are developing therapeutic approaches to diseases using drugs that influence receptor activation.

Zielgruppe

Biochemists, molecular biologists, pharmacologists, neurobiologists, cell biologists, and pharmaceutical scientists.

Autoren/Hrsg.

Haga, Tatsuya

Takeda, Shigeki

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Naturwissenschaften Biowissenschaften Proteinforschung
• Naturwissenschaften Biowissenschaften Biowissenschaften Neurobiologie, Verhaltensbiologie

Inhaltsverzeichnis

Screening of Ligands for GPCRs
Screening of Endogenous Ligands for Orphan GPCRs, M. Mori, S. Hinuma, T. Ohtaki, and M. Fujino
Screening of Ligands for Human GPCRs by the Use of Receptor-Ga ( Fusion Proteins, S. Takeda, H. Suga, and T. Haga
Screening and Identification of Ghrelin, an Endogenous Ligand for the Growth-Hormone-Secretagogue Receptor, M. Kojima and K. Kangawa
Ligand Screening of Olfactory Receptors, K. Touhara, S. Katada, T. Nakagawa, and Y. Oka
Functions and Regulations of GPCRs
Generation and Phenotypical Analysis of Muscarinic Acetylcholine Receptor Knockout Mice, J. Wess, D. Gautam, S.-J. Han, J. Jeon, C. Li, and C. Deng
Systematic Mutagenesis of M1 Muscarinic Acetylcholine Receptors, E.C. Hulme
Analysis of the Regulation of Muscarinic Acetylcholine Receptors, C.J. Van Koppen
Single-Molecule Analysis of Chemotactic Signaling Mediated by cAMP Receptor on Living Cells, M. Ueda, Y. Miyanaga, and T. Yanagida
Oligomerization of G Protein-Coupled Purinergic Receptors, H. Nakata, K. Yoshioka, and T. Kamiya Tertiary Structure of GPCRs and Their Ligands
Methods and Results in X-Ray Crystallography of Bovine Rhodopsin, T. Okada, R. Tsujimoto, M. Muraoka, and C. Funamoto
Determination of Steric Structure of Muscarinic Ligands Bound to Muscarinic Acetylcholine Receptors: Approaches by TRNOE (Transferred Nuclear Overhauser Effect), H. Furukawa, T. Hamada, H. Hirota, M. Ishiguro, and T. Haga
Modeling of G Protein-Coupled Receptors for Drug Design, M. Ishiguro
Index