Hadjiliadis / Sletten Metal Complex - DNA Interactions

1. Auflage 2009
ISBN: 978-1-4051-9410-5
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 544 Seiten, E-Book

Metal ions and metal complexes have long been recognized ascritically important components of nucleic acid chemistry, both inregulation of gene expression and as promising therapeutic agents.Understanding how metal complexes interact with DNA has become anactive research area at the interface between chemistry, molecularbiology and medicine.
Metal Complex - DNA Interactions provides a comprehensiveoverview of this increasingly diverse field, presenting recentdevelopments and the latest research with particular emphasis onmetal-based drugs and metal ion toxicity. The text is divided intofour parts:
* Basic Structural and Kinetic Aspects: includes chapterson sequence-selective metal binding to DNA and thermodynamicmodels.
* Medical Applications: focuses on anticancer platinumdrugs, including discussions on DNA repair in antitumor effects ofplatinum drugs and photo-dynamic therapy.
* DNA-Recognition - Nucleases and Sensor: describesprobes for DNA recognition, artificial restriction agents,metallo-DNAzymes for metal sensing applications and metal iondependent catalysis in nucleic acid enzymes.
* Toxicological Aspects: deals with structural studies ofmercury-DNA interactions, chromium-induced DNA damage andrepair, and the effect of arsenic and nickel on DNAintegrity.
This book will be a valuable resource for academic researchersand professionals from a range of pharmaceutical and chemicalindustries, particularly those involved in the development of newand less toxic anticancer metallo-drugs, and in the field ofenvironmental and toxicological chemistry.

Autoren/Hrsg.

Hadjiliadis, Nick

Sletten, Einar

Inhaltsverzeichnis

A Basic Structural and Kinetic Aspects
1. Sequence-Selective Binding of Transition Metal Complexes toDNA
2. Thermodynamic Models of Metal Ion -DNA.Interactions
3. Metal Ion Coordination in G-quadruplexes
4. Supramolecular Chemistry of Metal-Nucleobase Complexes
B Medical Applications
5. Platinum Drugs, Nucleotides, and DNA: the Role of InterligandInteractions,
nucleotides and DNA
6. Role of DNA Repair in Antitumor Effects of Platinum Drugs
7. Telomeres and Telomerase: Potential Targets for PlatinumComplexes
8. Toward Photodynamic Therapy of Cancer with Platinum GroupMetal Polyazine Complexes
9. Platinated Oligonucleotides: Synthesis and Applications forthe Control of Gene
Expression
10. New Titanium and Ruthenium Anticancer Drugs and theirInteraction with DNA
C DNA-Recognition - Nucleases and Sensors
11. Groove-Binding Ruthenium(II) Complexes as Probes of DNARecognition
12. DNA Recognition and Binding by Peptide-Metal Complexconjugate
13. Artificial Restriction Agents - Hydrolytic Agents for DNACleavage
14. New Metallo-DNAzymes: Fundamental Studies of Metal-DNAInteractions and
Metal Sensing Applications
15. Two-metal Ion Dependent Catalysis in Nucleic AcidEnzymes
D Toxicological aspects
16. Mercury- DNA Interactions. Structural Studies onMercury¯II -Mediated T-T Base-Pair with NMRSpectroscopy
17. Chromium-Induced DNA Damage and Repair
18. Arsenic and nickel: Mechanisms Affecting DNA Integrity

Über Autor(innen)

Nikolaos Hadjiliadis is Professor in the Dept of Chemistry at the University of Ioannina, Greece. Einar Sletten is Professor in the Dept of Chemistry at the University of Bergen, Norway.