Hematopoiesis

Biochemical, Cellular, Molecular, and Genomic Perspectives
1. Auflage 2024
ISBN: 978-1-77491-472-4
Verlag: Apple Academic Press

Buch, Englisch, 318 Seiten, Format (B × H): 161 mm x 240 mm, Gewicht: 646 g

Reihe: Modern Trends in Molecular Biology

This new volume discusses the widespread concerns of hematopoietic challenges in different and emerging ways. With chapters written by faculty and researchers from prestigious institutions working directly in hematopoiesis and advanced areas of biology, the volume offers a comprehensive overview of the regulation of blood cell development, epigenetic mechanisms, and regulatory non-coding RNAs. It presents concepts related to regulation of hematopoietic stem cell development, as well as survival, proliferation, and differentiation. It also discusses the microenvironmental niche where stem cells exist and develop into distinct blood cell types. A model system used to study non-coding RNA functions along with transformation of normal cells into cancer cell is elaborated on as well.

Key features of the book:

- Details how to utilize the available investigative tools and techniques to isolate and study single blood cells in different model systems

- Discusses the epigenetics of hematopoiesis

- Considers the clinical outcomes of defective hematopoiesis

- Describes hematopoiesis and cancer stem cells

- Looks at hematopoiesis in relation to specific diseases, such as minimal residual disease (MRD) and leukemia

This book provides valuable information related to developments in hematopoiesis that will be helpful for understanding the basics of hematopoiesis and the clinical treatment of blood diseases. Hematopoiesis: Biochemical, Cellular, Molecular, and Genomic Perspectives will be valuable to clinicians, medical school students, and researchers working in hematology.

Zielgruppe

Academic and Postgraduate

Autoren/Hrsg.

Gutti, Ravi Kumar

Fachgebiete

• Naturwissenschaften Biowissenschaften Biowissenschaften
• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Biochemie (med.)
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Hämatologie, Transfusionsmedizin

Inhaltsverzeichnis

1. Unrevealing the Mechanism of Zebrafish Hematopoiesis: A Novel Approach 2. Investigative Tools to Study Blood Cells: Focus on Single Cell Isolation and Analysis 3. Evaluation of Chitosan and Its Derivatives in Immunomodulating Blood Sentinel Cells 4. Proteoglycans and Glycosaminoglycans Regulating Functions of the Hematopoietic Stem Cell Niche 5. Epigenetics of Hematopoiesis: Role of HATs and HDACs 6. Systems Biology Approaches Toward Understanding Human Long Non-Coding RNA Hematopoietic Cells 7. Clinical Outcomes of Defective Hematopoiesis 8. Circulating Messengers of Blood and Their Clinical Applications 9. Hematopoiesis and Cancer Stem Cells: The Seed and the Soil Crosstalk 10. lncRNAs in Types of Leukaemia 11. Minimal Residual Disease (MRD) as a Prognostic Factor in Acute Myeloid Leukaemia

Über Autor(innen)

Ravi Kumar Gutti, PhD, is Professor in the Department of Biochemistry of the School of Life Sciences at the University of Hyderabad, India. He has extensive research and teaching experience from Harvard Medical School (USA), National Institutes of Health (USA), Moffitt Cancer and Research Centre (USA), and RWTH Aachen (Germany). His research primarily focuses on understanding the molecular mechanisms in low platelet diseases and is well funded by several grants from the Government of India and other organizations. He has received awards and recognition from several prominent national and international organizations, including a Chancellor's Award from the University of Hyderabad for making significant contributions to teaching and research. Dr. Gutti has authored several publications in reputed international journals and has presented his research at international scientific meetings.