Gusev MicroRNA Profiling in Cancer

A Bioinformatics Perspective
1. Auflage 2011
ISBN: 978-981-4267-54-0
Verlag: Pan Stanford Publishing
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 257 Seiten

This book presents current advances in the emerging interdisciplinary field of microRNA research of human cancers from a unique perspective of quantitative sciences: bioinformatics, computational and systems biology, and mathematical modeling. This volume contains adaptations and critical reviews of recent state-of-the-art studies, ranging from technological advances in microRNA detection and profiling, clinically oriented microRNA profiling in several human cancers, to a systems biology analysis of global patterns of microRNA regulation of signaling and metabolic pathways. Interactions with transcription factor regulatory networks and mathematical modeling of microRNA regulation are also discussed.

Zielgruppe

Academic, biotech, and pharmaceutical industry biomedical scientists; physicians involved in cancer research; oncologists; computational biologists and bioinformaticians who are involved in basic, translational and clinical research; college educators; and undergraduate, graduate, and medical students.

Autoren/Hrsg.

Gusev, Yuriy

Fachgebiete

• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Pharmazeutische Technologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Pharmazie
• Mathematik | Informatik EDV | Informatik Angewandte Informatik Bioinformatik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Onkologie, Krebsforschung
• Naturwissenschaften Biowissenschaften Angewandte Biologie Bioinformatik
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Biotechnologie Medizinische Biotechnologie

Inhaltsverzeichnis

Measurement and Interpretation of MiRNA Expression Profiles
MicroRNA Expression Analysis by LNA Enhanced Microarrays
Analysis and QC for Real-Time QPCR Arrays of Human MicroRNAs
Massively Parallel MicroRNA Profiling in the Haematologic Malignancies
Who Dunit? MicroRNAs Involved in Prostate Cancer
Intronic MicroRNA
Creation, Evolution and Regulation
Mirome Architecture and Genomic Instability
Interconnection of MicroRNA and Transcription Factor-Mediated Regulatory Networks
Analysis of MicroRNA Profiling Data with Systems Biology Tools
Mathematical and Computational Modeling of Post-Transcriptional Gene Regulation by MicroRNAs

Über Autor(innen)

Yuriy Gusev, PhD, assistant professor in Bioinformatics, Department of Surgery, at the University of Oklahoma Health Sciences Center, is instrumental in the ongoing development and activities of a surgical research facility focused on molecular and cellular studies of human diseases related to surgery. He is responsible for the management of computerized cell imaging and bioinformatics systems for gene expression micro-arrays technologies in Surgical Research Core Facilities as well as the education of residents, postdoctoral fellows, and medical and graduate students.