Emerging Modern Microfluidics Driven Automations

Perspectives in Drug Discovery, Drug Delivery, Diagnostics, and Regulatory Concerns
Erscheinungsjahr 2022
ISBN: 978-0-12-822633-9
Verlag: Elsevier Science

Buch, Englisch, 440 Seiten, Format (B × H): 152 mm x 229 mm

Emerging Modern Microfluidics Driven Automations: Perspectives in Drug Discovery, Drug Delivery, Diagnostics, and Regulatory Concerns explores the fundamentals, applications and future direction of microfluidics in pharmaceutical science. The book discusses novel methodologies with diversified applications, especially in the theragnostic and biomedical arenas. Covering areas of modern microfluidics in drug discovery, drug delivery, diagnostics and regulatory concerns, the book has a special focus on the intellectual abilities of the process or product viability of microfluidics. Other topics include the applications of microfluidics for processing of biomaterials and nanomedicines, toxicological studies, disease/tumor 3D in vitro models, 3D printing of microfluidics, and personalized medicine applications.

With contributions from authors in industry and academia, this resource is ideal for early-career pharmaceutical and biomedical engineering professionals involved in developing new tools for the delivery of therapeutics, novel drug discovery and medical diagnostics using Microfluidics technology.

Autoren/Hrsg.

Gupta, Vivek

Kurakula, Mallesh

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Medizintechnik, Biomedizintechnik, Medizinische Werkstoffe
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Biotechnologie
• Technische Wissenschaften Maschinenbau | Werkstoffkunde Technische Mechanik | Werkstoffkunde
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Pharmazie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Technische Wissenschaften Sonstige Technologien | Angewandte Technik Medizintechnik, Biomedizintechnik

Inhaltsverzeichnis

Part I - Fundamentals
1. Introduction to microfluidics - physics, and applications
2. Fluid Dynamics in microfluidics
3. Microfluidic-assisted organic synthesis
4. Introduction to microfabrication and applications in biomedical sciences

Part II - Applications in Drug Discovery
5. Microfluidics in cell culture systems
6. Single-cell screening using microfluidic systems
7. Microfluidic Vascular Networks for Engineered Tissues
8. Microscale Models of Inflammatory Diseases
9. Lab-on-a-chip techniques for high throughput proteomics and drug discovery
10. Organ-on-chip systems for personalized medicine
11. Antibody discovery using microfluidic systems

Part III - Applications in Drug Delivery
12. Microfabrication and Microfluidic Devices for Drug Delivery
13. Microfluidic mixing and devices for preparing nanoparticulate drug delivery systems
14. Droplet-based microfluidics for cell encapsulation and delivery
15. Lab-on-a-chip synthesis of microparticles for drug encapsulation and controlled release
16. Microfluidic technologies for local drug delivery
17. Applications of microfluidics for processing of biomaterials and nanomedicines
18. 3D printing using microfluidics

Part IV - Applications in Diagnostics
19. Introduction, structuring, and application of electrowetting Theory (EWOD) Microsystems in diagnostics
20. Introduction, structuring, and application of liquid dielectrophoresis in diagnostics.
21. Digital microfluidics technologies for diagnostic devices
22. Microfluidic devices for stem cell analysis
23. Development of immunoassays for protein analysis on nanobioarray chips
24. Applications of disease/tumour 3D in vitro models

Part V- Intellectual and Regulatory Perspective
25. Current and future impact of microfluidic technology
26. Challenges to scaling up, commercialization, intellectual property, and regulatory issues

Über Autor(innen)

Gupta, Vivek
Dr. Vivek Gupta received his Ph.D. in pharmaceutical sciences from Texas Tech University Health Sciences Center, Amarillo, TX. He is currently an assistant professor of industrial pharmacy and pharmaceutics at St. John's University in New York City. He has more than 10 years of experience in formulation design for novel drug delivery systems for non-invasive delivery of therapeutics, pharmacokinetic and pharmacodynamic characterization of delivery systems for enhanced lung accumulation and bioavailability. Dr. Vivek Gupta's current research is focused on drug discovery and delivery of novel therapeutic agents for rare disorders of the cardiopulmonary system including pulmonary fibrosis, pulmonary hypertension, and mesothelioma, a rare form of lung cancer associated with asbestos exposure. Dr. Gupta has published 45 journal articles and book chapters in his research field.

Kurakula, Mallesh
Dr. Mallesh Kurakula received his Ph.D. in Chemistry from King Abdul-Aziz University, Jeddah, KSA. He is currently a research scientist in the department of biomedical engineering at the University of Memphis, TN. He has a bachelor and postgraduation in pharmacy, having pharmaceutics as specialization. His research is focused on evaluating polymers/ phospholipids of different origins in formulating novel delivery systems intended for enhancing the bioavailability and efficacy of BCS II drugs via different routes. Delivery systems were developed using a cross-section of state-of-the-art technologies such as electrospinning, 3D printing, and high-pressure homogenizers. Currently, he is working on an NIH grant project. He has published his research and book chapters in reputed journals in the fields of pharmaceutics, biopolymers, nanotechnology and biomedical fields.