Gunning Tropomyosin

1. Auflage 2009
ISBN: 978-0-387-85766-4
Verlag: Springer
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band 644, 304 Seiten

Reihe: Advances in Experimental Medicine and Biology

A recent review of one of my grant applications commented on the 'rediscovery of tropomyosin'. I was tempted to write back in my rebuttal to the reviewer that I didn't realise it had been lost. Uncharacteristic maturity prevailed and I resisted the temptation, but I was struck by the underlying observation that research on the str- ture and function of tropomyosin has been somewhat invisible, particularly in terms of the cytoskeleton isoforms. So, how can it be that one of the two major components of the actin filament has been so thoroughly overlooked? I suspect that the answer is disappointingly pedestrian. Whereas the biochemistry of the 1980s revealed the potential of tropomyosin isoforms to diversify the function of actin filaments, the subsequent disenchantment with isoform biology in general in the 1990s inhibited growth of this field. With the development of more sophisticated experimental - proaches we are now seeing a growing realisation of the importance of tropomyosin in regulating actin filaments beyond its pivotal role in muscle contraction. The opportunity to edit this book came at a time when we had written several reviews on different aspects of tropomyosin function and I had just finished the background reading for a comprehensive review of tropomyosin biology. I realised that the field was simply beyond the capacity of any one person to do the field j- tice.

PETER GUNNING, PhD, is Head of the Oncology Research Unit, Department of Pharmacology, School of Medical Sciences, at the University of New South Wales located in Sydney, Australia. The primary focus of his research is the regulation of cell and tissue architecture and its modification in cancer. He is a member of numerous professional organisations and has served on the Boards of the NSW Cancer Council and Bio-Link Partners and as Chairman of the NSW Cancer Council and NSW Cancer Institute Research Committees. Peter received his academic degrees from Monash University, Melbourne, Australia.

Autoren/Hrsg.

Gunning, Peter

Inhaltsverzeichnis

1;PREFACE;6
2;ABOUT THE EDITOR...;8
3;PARTICIPANTS;9
4;CONTENTS;13
5;1 Introduction and Historical Perspective;20
6;2 Structure and Evolution of Tropomyosin Genes;25
7;3 Tropomyosin Exons as Models for Alternative Splicing;46
8;4 Tropomyosin Gene Expression in Vivo and in Vitro;62
9;5 Tropomyosin: Function Follows Structure;79
10;6 Dimerization of Tropomyosins;92
11;7 Cooperative Binding of Tropomyosin to Actin;104
12;8 Tropomyosin and the Steric Mechanism of Muscle Regulation;114
13;9 Role of Tropomyosin in the Regulation of Contraction in Smooth Muscle;129
14;10 Tropomyosin as a Regulator of Cancer Cell Transformation;143
15;11 The Role of Tropomyosin in Heart Disease;151
16;12 Tropomyosins in Skeletal Muscle Diseases;162
17;13 Tropomyosins in Human Diseases: Ulcerative Colitis;177
18;14 Tropomyosin Function in Yeast;187
19;15 Isoform Sorting of Tropomyosins;206
20;16 Human Tropomyosin Isoforms in the Regulation of Cytoskeleton Functions;220
21;17 Tropomyosins Regulate the Impact of Actin Binding Proteins on Actin Filaments;242
22;18 Tropomyosin and ADF/ Cofilin as Collaborators and Competitors;251
23;19 Caldesmon and the Regulation of Cytoskeletal Functions;269
24;20 Tropomyosins as Discriminators of Myosin Function;292
25;21Tropomodulin/Tropomyosin Interactions Regulate Actin Pointed End Dynamics;302
26;22 Emerging Issues for Tropomyosin Structure, Regulation, Function and Pathology;312
27;Index;318