Grandin / Textor Intelligent Surfaces in Biotechnology

Scientific and Engineering Concepts, Enabling Technologies, and Translation to Bio-Oriented Applications
1. Auflage 2012
ISBN: 978-1-118-18121-8
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 400 Seiten, E-Book

A comprehensive overview of smart and responsive surfaces inbiotechnology and their applications
A wave of recent advances in cell biology, biophysics,chemistry, and materials science has enabled the development of anew generation of smart biomaterials. Intelligent Surfaces inBiotechnology: Scientific and Engineering Concepts, EnablingTechnologies, and Translation to Bio-Oriented Applications providesreaders with a comprehensive overview of surface modifications andtheir applications, including coverage of the physico-chemicalproperties, characterization methods, smart coating technologies,and demonstration of performance in vitro and in vivo.
The first part of the book covers applications in the fields ofbiosensing and biodiagnostics, while the second part focuses moreon coatings for medical devices, drug delivery, and tailoredcell-surface interactions. The book explores intelligent surfaceapplications such as tissue engineering, drug targeting anddelivery, wound healing and anti-infection strategies, biosensors,nanopatterning, and bioinspired design of novel responsivematerials and multifunctional surfaces.
Designed to aid scientists and engineers in understanding therapidly developing field of biofunctional surfaces, IntelligentSurfaces in Biotechnology is an edited volume with each chapterwritten by a respected expert and featuring examples taken from themost state-of-the-art developments in the discipline.
Cover Image: Design concept for a diagnostic microfluidic systembased on responsive polymer- and antibody-conjugated nanobeads (seeChapter 2 of this book, Figure 2.5; reproduced by permission fromthe Royal Society of Chemistry).

Autoren/Hrsg.

Grandin, H. Michelle

Textor, Marcus

Weitere Mitwirkende

Whitesides, George M.

Inhaltsverzeichnis

Chapter 1. Responsive Polymers as Intelligent Coatings for Biosensors: Architectures, Response Mechanisms, and Applications
Vinalia Tjong, Jianming Zhang, Ashutosh Chilkoti and Stefan Zauscher
1.1 Introduction
1.2 SRP Architectures for Biosensor Applications
1.3 Mechanisms of Response
1.4 Sensing and Transduction Mechanisms
1.5 Limitations and Challenges
1.6 Conclusion and Outlook
Chapter 2. Smart Surfaces for Point-of-Care Diagnostics
Michael A. Nash, Allison L. Golden, John M. Hoffman, James Lai, and Patrick S. Stayton
2.1 Introduction
2.2 Standard Methods for Biomarker Purification, Enrichment, and Detection
2.3 Smart Reagents for Biomarker Purification and Processing
2.4 Sample-Processing Modules for Smart Conjugate Bioassays
2.5 Devices for use in Smart Conjugate Bioassays
2.6 Conclusions
Chapter 3. Design of Intelligent Surface Modifications and Optimal Liquid Handling for Nanoscale Bioanalytical Sensors
Laurent Feuz, Fredrik Höök and Erik Reimhult
3.1 Introduction
3.2 Orthogonal small (nano) scale surface modification using molecular self-assembly
3.3 Alternative surface patterning strategies
3.4 The challenge of analytic transport
3.5 Concluding remarks
Chapter 4. Intelligent Surfaces for Effect Based Nano-biosensing
Akira Matsumoto, Yuji Miyahara and Kazunori Kataoka
4.1 Introduction
4.2 Field effect transistor based biosensors
4.3 Intelligent surfaces for signal transduction and amplification of Bio-FETs
4.4 New targets of Bio-FETs
4.5 Future Perspective
Chapter 5. Supported Lipid Bilayers: Intelligent Surfaces for Ion Channel Recordings
Andreas Janshoff and Claudia Steinem
5.1 Introduction
5.2 Supported lipid bilayers
5.3 Characterizatics of SSMs
5.4 Ion channels in SSMs
5.5 Future perspective: Ion channels in micropatterned membranes
Chapter 6. Antimicrobial and Anti-inflammatory Intelligent Surfaces
Hans J. Griesser, Heike Hall, Toby Jenkins, Stefani S. Griesser and Krasimir Vasilev
6.1 Introduction
6.2 Antibacterial strategies
6.3 Bioactive antibacterial surfaces
6.4 Stimulus-responsive antibacterial coatings for wound dressings
6.5 Anti-inflammatory surfaces
6.6 Conclusions and Outlook
Chapter 7. Intelligent Polymer Thin Films and Coatings for Drug Delivery
Alexander N. Zelikin and Brigitte Städler
7.1 Introduction
7.2 Surface Mediated Drug Delivery
7.3 Drug Delivery Vehicles With Functional Polymer Coatings
7.4 Outlook
Chapter 8. Micro- and Nanopatterning of Active Biomolecules and Cells
Daniel Aydin, Vera C. Hirschfeld-Warneken, Ilia Louban and Joachim P. Spatz
8.1 Introduction
8.2 Chemical Approaches for Protein Immobilization
8.3 Biomolecule patterning by "top-down" techniques
8.4 Biomolecule Nanoarrays bu Block Copolymer Nanolithography
8.5 Application of Nanostructured Surfaces to Study Cell Adhesion
8.6 Conclusion
Chapter 9. Responsive Polymer Coatings for Smart Applications in Cromatography, Drug Delivery Systems and Cell Sheet Engineering
Rogério P. Pirraco, Masayuki Yamato, Yoshikatsu Akiyama, Kenichi Nagase, Masamichi Nakayama, Alexandra P. Marques, Rui L. Reis and Teruo Okano
9.1 Introduction
9.2 Temperature-responsive chromatography
9.3 Temperature-responsive polymer micelle
9.4 Temperature-responsive culture surfaces
9.5 Cell sheet Engineering
9.6 Conclusions

Über Autor(innen)

H. Michelle Grandin currently works as a scientific writerand consultant in the field of tissue regeneration and implantsurfaces for dental applications. Previously, she worked as asenior research scientist in the biointerface group of MarcusTextor at ETH Zurich. There, she developed a waveguide fluorescencemicroscope for the study of bio-interactions in the near-field aswell as leading a group in the development of 3D single cellularmicrowell arrays for application in stem cell and cancer research.
Marcus Textor is a Professor Emeritus at ETH Zurich,Department of Materials. He was head of a research group dedicatedto surfaces and interfaces in bio-related fields of materialscience. His research interests cover both fundamental aspects ofthe behavior of materials in contact with biological milieus andthe design and development of surfaces that elicit biospecificresponses.