E-Book, Englisch, 525 Seiten, Web PDF
Goyer Metal Toxicology
1. Auflage 2013
ISBN: 978-1-4832-8856-7
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark
Approaches and Methods
E-Book, Englisch, 525 Seiten, Web PDF
ISBN: 978-1-4832-8856-7
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark
Metal Toxicology addresses the effects of metals on human health, as well as their mechanisms of toxicity. Unlike most books on metal toxicity which are organized by individual metals, this book is arranged inan organ-by-organ basis. It deals with unifying mechanisms of metal toxicity within a given tissue, and with exposure of a tissue to more than one metal at a time.Unique aspect of organ-specific orientationWritten by leading authorities in metal toxicologyChapters of special interest include Risk Assessment, Emerging Technologies, and Molecular Biological TechniquesServes as an excellent sourcebook of generalized information on metal toxicology, allowing for specific tissue-system referencing
Autoren/Hrsg.
Weitere Infos & Material
1;Front Cover;1
2;Metal Toxicology;4
3;Copyright Page;5
4;Table of Contents;6
5;Contributors;18
6;Preface;22
7;PART I: GENERAL PRINCIPLES;26
7.1;Chapter 1. Metal Disposition: An Analysis of Underlying Mechanisms;28
7.1.1;I. INTRODUCTION;28
7.1.2;II. METAL ABSORPTION;30
7.1.3;III. TRANSPORT OF TNEM IN BLOOD;38
7.1.4;IV. MECHANISM OF CELLULAR TNEM UPTAKE IN TARGET ORGANS;40
7.1.5;V. CELLULAR TRAPPING OF TNEM AND THEIR RELEASE;43
7.1.6;VI. EXCRETION OF TNEM;47
7.1.7;VII. APPROACH TO STEADY STATE: TOXICOLOGICAL IMPLICATIONS;48
7.1.8;VIII. CONCLUSIONS;49
7.1.9;REFERENCES;49
7.2;Chapter 2. Factors Influencing Metal Toxicity;56
7.2.1;I. INTRODUCTION;56
7.2.2;II. ESSENTIAL METALS;57
7.2.3;III. METAL-BINDING PROTEINS;61
7.2.4;IV. ETHANOL;62
7.2.5;V. AGE AND DEVELOPMENT;63
7.2.6;VI. GENETICS;66
7.2.7;REFERENCES;66
7.3;Chapter 3. Metal Carcinogenesis;72
7.3.1;I. INTRODUCTION;72
7.3.2;II. CHARACTERISTICS OF METALS AS TOXINS OR CARCINOGENS;73
7.3.3;III. PROBLEMS IN ASSESSING CARCINOGENIC RISK FROM METALS;74
7.3.4;IV. METALS AS HUMAN CARCINOGENS;76
7.3.5;V. METALS AS CARCINOGENS IN ANIMALS;79
7.3.6;VI. TARGET SITES OF THE CARCINOGENIC METALS;79
7.3.7;VII. TARGET SITE SPECIFICITY IN METAL CARCINOGENESIS;84
7.3.8;VIII. DUALITIES IN METAL CARCINOGENESIS;85
7.3.9;IX. HYPOTHETICAL MECHANISMS IN METAL CARCINOGENESIS;86
7.3.10;X. METAL-METAL INTERACTIONS IN METAL CARCINOGENESIS;88
7.3.11;XI. SUMMARY;89
7.3.12;REFERENCES;89
7.4;Chapter 4. Organ-Specific Therapeutic Intervention;96
7.4.1;I. INTRODUCTION;96
7.4.2;II. BLOOD, MARROW, BONE;99
7.4.3;III. IMMUNOTOXICITY;105
7.4.4;IV. LIVER TOXICITY;106
7.4.5;V. KIDNEY;110
7.4.6;VI. NEUROTOXICITY;113
7.4.7;VII. CARDIOVASCULAR;119
7.4.8;VIII. RESPIRATORY;119
7.4.9;IX. SKIN TOXICITY;120
7.4.10;X. REPRODUCTIVE TOXICITY;121
7.4.11;REFERENCES;124
7.5;Chapter 5. Molecular Techniques in Metal Toxicology;136
7.5.1;I. INTRODUCTION;136
7.5.2;II. MEASURING GENETIC CHANGES IN RESPONSE TO METALS;139
7.5.3;III. INTERVENTION IN CONTROL OF GENE EXPRESSION IN EUKARYOTES;152
7.5.4;IV. CELLULAR RESPONSE TO INTERVENTION IN GENE EXPRESSION;156
7.5.5;V. SUMMARY;158
7.5.6;ACKNOWLEDGMENT;158
7.5.7;REFERENCES;158
7.6;Chapter 6. Risk Assessment;166
7.6.1;I. INTRODUCTION;166
7.6.2;II. HAZARD IDENTIFICATION;167
7.6.3;III. DOSE-RESPONSE ASSESSMENT;172
7.6.4;IV. EXPOSURE ASSESSMENT;181
7.6.5;V. RISK CHARACTERIZATION;191
7.6.6;VI. USE OF RISK ASSESSMENT FOR METALS IN THE REGULATORY PROCESS;200
7.6.7;VII. CONCLUSIONS;205
7.6.8;REFERENCES;206
7.7;Chapter 7. Toxic Metals in Emerging Technologies;212
7.7.1;I. INTRODUCTION;212
7.7.2;II. CHEMICAL DISPOSITION STUDIES;213
7.7.3;III. BIOLOGICAL EFFECTS;214
7.7.4;IV. FUTURE RESEARCH DIRECTIONS;217
7.7.5;ACKNOWLEDGEMENTS;218
7.7.6;REFERENCES;218
8;PART II: TARGET ORGANS;222
8.1;Chapter 8. Nervous System;224
8.1.1;I. INTRODUCTION;224
8.1.2;II. INORGANIC AND ORGANIC MERCURY;225
8.1.3;III. INORGANIC AND ORGANIC LEAD;232
8.1.4;IV. ALUMINUM;239
8.1.5;V. TIN;242
8.1.6;VI. TELLURIUM;244
8.1.7;VII. ARSENIC;245
8.1.8;VIII. MANGANESE;246
8.1.9;REFERENCES;248
8.2;Chapter 9. Respiratory System;262
8.2.1;I. INTRODUCTION;262
8.2.2;II. ADVERSE LUNG EFFECTS OF INHALED METALS;268
8.2.3;III. MODULATING FACTORS OF METAL TOXICITY;283
8.2.4;REFERENCES;285
8.3;Chapter 10. The Effects of Arsenic, Lead, and Cadmium on the Cardiovascular System1;290
8.3.1;I. INTRODUCTION;290
8.3.2;II. ARSENIC;291
8.3.3;III. LEAD;294
8.3.4;IV. CADMIUM;299
8.3.5;ACKNOWLEDGMENT;304
8.3.6;REFERENCES;304
8.4;Chapter 11. Hematopoietic System;312
8.4.1;I. INTRODUCTION;312
8.4.2;II. HEMATOPOIETIC EFFECTS OF INDIVIDUAL METALS;313
8.4.3;ACKNOWLEDGMENT;325
8.4.4;REFERENCES;325
8.5;Chapter 12. Immune Modulation by Toxic Metals;330
8.5.1;I. INTRODUCTION;330
8.5.2;II. LEAD EFFECTS ON THE IMMUNE SYSTEM;332
8.5.3;III. CADMIUM EFFECTS ON IMMUNITY;345
8.5.4;IV. MERCURY EFFECTS ON THE IMMUNE SYSTEM;347
8.5.5;V. SUMMARY;353
8.5.6;ACKNOWLEDGMENT;354
8.5.7;REFERENCES;354
8.6;Chapter 13. Hepatotoxicity of Metals1;364
8.6.1;I. INTRODUCTION;364
8.6.2;II. CADMIUM;365
8.6.3;III. ARSENIC;371
8.6.4;IV. CONCLUSION;377
8.6.5;REFERENCES;378
8.7;Chapter 14. Metals Lesions of the Gastrointestinal Tract;388
8.7.1;I. INTRODUCTION;388
8.7.2;II. INFLAMMATORY LESIONS OF THE ESOPHAGUS AND STOMACH;389
8.7.3;III. SQUAMOUS CARCINOMA OF THE ESOPHAGUS;394
8.7.4;IV. SMALL INTESTINE;397
8.7.5;V. ADENOCARCINOMA OF THE SMALL AND LARGE INTESTINE;405
8.7.6;REFERENCES;408
8.8;Chapter 15. Renal Effects of Metals;414
8.8.1;I. INTRODUCTION;414
8.8.2;II. SUSCEPTIBILITY TO RENAL TOXICITY;415
8.8.3;III. MECHANISMS AND PATHOLOGY;417
8.8.4;IV. BIOMARKERS OF RENAL INJURY BY METALS;418
8.8.5;V. NEPHROTOXICITY OF SPECIFIC METALS;420
8.8.6;VI. SUMMARY;432
8.8.7;REFERENCES;432
8.9;Chapter 16. Gonadal-Specific Metal Toxicology;438
8.9.1;I. GENERAL INTRODUCTION;438
8.9.2;II. TESTES: TARGET ORGAN FOR CHEMICAL INJURY;440
8.9.3;III. CONCLUDING REMARKS;458
8.9.4;II. OVARY;459
8.9.5;ACKNOWLEDGMENT;462
8.9.6;REFERENCES;462
8.10;Chapter 17. Skin;472
8.10.1;I. INTRODUCTION;472
8.10.2;II. CONTACT DERMATITIS;476
8.10.3;III. RISK ASSESSMENT;485
8.10.4;REFERENCES;486
8.11;Chapter 18. Metal-Induced Osteotoxicities;490
8.11.1;I. INTRODUCTION;490
8.11.2;II. CADMIUM;494
8.11.3;III. LEAD;507
8.11.4;IV. ALUMINUM;517
8.11.5;ACKNOWLEDGMENTS;522
8.11.6;REFERENCES;523
9;Index;536