Mood and Anxiety Related Phenotypes in Mice

Characterization Using Behavioral Tests
2010
ISBN: 978-1-60761-302-2
Verlag: Humana Press

Buch, Englisch, 334 Seiten, Format (B × H): 198 mm x 266 mm, Gewicht: 1167 g

Reihe: Neuromethods

Affecting approximately twenty percent of the world population, mood and anxiety disorders have been the subject of ever-increasing research. This increased research parallels a remarkable growth in the use of the laboratory mouse as a tool to understand the biological and genetic basis of mood and anxiety disorders as well as to develop improved treatments. In , world-renowned researchers provide an overview of behavioral approaches utilized in the characterization of mood and anxiety related behaviors in mice as well as commonly used behavioral assays to assess the potential antidepressant and anxiolytic efficacy of novel compounds. As a volume in the successful ™ series, the chapters provide authoritative reviews including up-to-date detailed protocols of the most commonly used approaches in the field.

is an ideal resource for scientists actively pursuing or interested in establishing behavioral protocols in their laboratories, while also serving as a reference for those students, scientists, and practitioners who have an interest in better understanding the preclinical behavioral methods used in mood and anxiety research.

Zielgruppe

Professional/practitioner

Autoren/Hrsg.

Gould, Todd D

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft
• Interdisziplinäres Wissenschaften Wissenschaften Interdisziplinär Neurowissenschaften, Kognitionswissenschaft
• Naturwissenschaften Biowissenschaften Biowissenschaften Neurobiologie, Verhaltensbiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Biomedizin, Medizinische Forschung, Klinische Studien

Inhaltsverzeichnis

The Open Field Test.- Analysis of Grooming Behavior and Its Utility in Studying Animal Stress, Anxiety, and Depression.- Digging in Mice: Marble Burying, Burrowing, and Direct Observation Reveal Changes in Mouse Behavior.- Circadian and Light Modulation of Behavior.- Ultrasonic Vocalizations by Infant Mice: An Ethological Expression of Separation Anxiety.- The Forced Swimming Test in Mice: A Suitable Model to Study Antidepressants.- The Tail-Suspension Test: A Model for Characterizing Antidepressant Activity in Mice.- Stress-Induced Hyperthermia in the Mouse.- Factors of Reproducibility of Anhedonia Induction in a Chronic Stress Depression Model in Mice.- Learned Helplessness in Mice.- The Mouse Light–Dark Box Test.- Using the Elevated Plus Maze as a Bioassay to Assess the Effects of Naturally Occurring and Exogenously Administered Compounds to Influence Anxiety-Related Behaviors of Mice.- Novelty-Induced Hypophagia.- Acute and Chronic Social Defeat: Stress Protocols and Behavioral Testing.- Reduction of Submissive Behavior Model for Antidepressant Drug Testing in Mice.- Mice Models for the Manic Pole of Bipolar Disorder.