Gossen / Kaufmann / Triezenberg Transcription Factors

Erscheinungsjahr 2012
ISBN: 978-3-642-18932-6
Verlag: Springer
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band 166, 581 Seiten, eBook

Reihe: Handbook of Experimental Pharmacology

Zielgruppe

Research

Autoren/Hrsg.

Gossen, Manfred

Kaufmann, Jörg

Triezenberg, Steven J.

Inhaltsverzeichnis

1. An Introduction to Transcription Factors.- Mechanisms of Transcriptional Activation in Eukaryotes.- Multiple Mechanisms of Transcriptional Repression in Eukaryotes.- Genomic Approaches to the Study of Transcription Factors.- 2. Transcription Factors in Pathophysiology.- Biological Roles of the STAT Family in Cytokine Signaling.- Members of the T-Cell Factor Family of DNA-Binding Proteins and Their Roles in Tumorigenesis.- Transcription Factors in the Control of Tumor Development and Progression by TGF-? Signaling.- The p53 Transcription Factor as Ther apeutic Target in Cancer.- The Role of Ets Transcription Factors in Mediating Cellular Transformation.- Function of the E2F Transcription Factor Family During Normal and Pathological Growth.- c-Myc in Cellular Transformation and Cancer.- NF-?B: Critical Regulator of Inflammation and the Immune Response.- Hepatitis BVirus X Protein: Structure-Function Relationships and Role in Viral Pathogenesis.- Regulation of Xenobiot ic Detoxification by PXR, CAR, GR, VDR and SHP Receptors: Consequences in Physiology.- 3. Exogenous Control of Transcription Factor Activity.- Potential of Transcription Factor Decoy Oligonucleotides as Therapeutic Approach.- Selective Estrogen Receptor Modulators as Therapeutic Agents in Breast Cancer Treatment.- Artificial Zinc Finger Peptides: A Promising Tool in Biotechnology and Medicine.- Tetracycline-Controlled Transactivators and Their Potential Use in Gene Therapy Applications.- Modulating Transcript ion with Artificial Regulators.