Gordon The Macrophage as Therapeutic Target

Erscheinungsjahr 2012
ISBN: 978-3-642-55742-2
Verlag: Springer
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band 158, 496 Seiten, eBook

Reihe: Handbook of Experimental Pharmacology

During the past decade, the rapid growth of molecular and cellular knowledge of macrophages, as a specialized host defense and homeostatic system, has begun to offer attractive targets for therapeutic intervention. Macrophages play a central role in a wide range of disease processes, from genetically determined lysosomal storage diseases, to acute sepsis, chronic inflammation and repair, tissue injury and cell death. Under- or overactivity of macrophage clearance, immune effector functions and responses to metabolic abnormalities contribute to common disorders such as autoimmunity, atherosclerosis, Alzheimer’s disease and major infections including AIDS and Tuberculosis. Whilst the goals of therapeutic intervention based on improved understanding of macrophage functions and their contribution to pathogenesis may seem self evident, there are considerable difficulties in producing useful new agents. The present volume covers a range of subjects and provides opportunities for a more focused macrophage-targeted approach. The individual chapters review selected topics briefly, to place cellular processes and molecular targets in perspective. Overall, the volume should provide a broad sample of the state of the art. Useful reviews and references in the literature are cited within individual chapters.

Zielgruppe

Research

Autoren/Hrsg.

Gordon, Siamon

Inhaltsverzeichnis

List of Contents.- 1. General.- The Macrophage as a Validated Pharmaceutical Target.- Transcription Factors that Regulate Macrophage Development and Function.- Exploitation of Macrophage Clearance Functions In Vivo.- Reaching the Macrophages: Routes of Delivery.- Antigen Presenting Cells and Vaccine Design.- Macrophage-Specific Gene Targeting In Vivo.- 2. Macrophage Targets in Inflammation.- Integrins of Macrophages and Macrophage-Like Cells.- Macrophage Targets in Inflammation: Purinergic Receptors.- Macrophage Lipid Uptake and Foam Cell Formation.- Dietary Fatty Acids and Macrophages.- Macrophages as Therapeutic Targets in Lysosomal Storage Disorders.- Nuclear Receptors as Regulators of Macrophage Homeostasis and Function.- Relationships between Reactive Oxygen Species and Reactive Nitrogen Oxide Species Produced by Macrophages.- Proteases.- Targeting the Chemokine System.- Antimicrobial Peptides.- Macrophage Phospholipid Products.- 3. Modulation of Specialised Macrophage Activities.- Dendritic Cells Versus Macrophages as Antigen-Presenting Cells: Common and Unique Features.- The Osteoclast.- Macrophages in the Central and Peripheral Nervous System.- Innate Recognition of Viruses by Macrophage and Related Receptors: Potential Ligand for Antiviral Agents.- Macrophage Immunity and Mycobacterium Tuberculosis.- Detection and Control of Fungi by Macrophages: The Role of Carbohydrates and Antifungal Agents.