Bioinformatics in Cancer and Cancer Therapy

2009
ISBN: 978-1-58829-753-2
Verlag: Humana Press

Buch, Englisch, 198 Seiten, Format (B × H): 190 mm x 266 mm, Gewicht: 659 g

Reihe: Cancer Drug Discovery and Development

Bioinformatics can be loosely defined as the collection, classification, storage, and analysis of biochemical and biological information using computers and mathematical algorithms. Bioinformatics represents a marriage of biology, medicine, computer science, physics, and mathematics, fields of study that have historically existed as mutually exclusive disciplines. Edited by Gavin Gordon, , the focus of this book is to provide a historical and technical perspective on the analytical techniques, methodologies, and platforms used in bioinformatics experiments, to show how a bioinformatics approach has been used to characterize various cancer-related processes, and to demonstrate how a bioinformatics approach is being used to bridge basic science and the clinical arena to positively impact patient care and management.

Zielgruppe

Research

Autoren/Hrsg.

Gordon, Gavin J.

Fachgebiete

• Naturwissenschaften Biowissenschaften Angewandte Biologie Bioinformatik
• Mathematik | Informatik EDV | Informatik Angewandte Informatik Bioinformatik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Onkologie, Krebsforschung

Inhaltsverzeichnis

The Emergence of Bioinformatics: Historical Perspective, Quick Overview and Future Trends.- The Statistical Design and Interpretation of Microarray Experiments.- Whole-Genome Analysis of Cancer.- Bioinformatics Approaches to the Analysis of the Transcriptome of Animal Models of Cancer.- Significance of Aberrant Expression of MicroRNAs in Cancer Cells.- Proteomic Methods in Cancer Research.- Comprehensive Genomic Profiling for Biomarker Discovery for Cancer Detection, Diagnostics and Prognostics.- Gene Expression Profiling of the Leukemias: Oncogenesis, Drug Responsiveness, and Prediction of Clinical Outcome.- Personalized Medicine in the Clinical Management of Colorectal Cancer.- Gene Alterations in Human Cancers.