Cell Cycle Inhibitors in Cancer Therapy

Current Strategies
2003. Auflage 2002
ISBN: 978-0-89603-930-8
Verlag: Humana Press

Buch, Englisch, 326 Seiten, Format (B × H): 156 mm x 234 mm, Gewicht: 653 g

Reihe: Cancer Drug Discovery and Development

Leading clinicians and investigators review in a comprehensible and user-friendly style all the latest information about the molecular biology of cell cycle control and demonstrate its clinical relevance to understanding neoplastic diseases. Topics range from Cdk inhibitors and cell cycle regulators to the prognostic value of p27 and tumor suppressor genes as diagnostic tools. Actual case studies show how the new molecular understanding has produced such drugs as Flavopiridol and Sulindac. The book brings all the recent critical research findings to bear on clinical practice, and clearly shows their powerful impact on the diagnostics, prognostics, and therapeutics of cancer, AIDS, and cardiovascular disease.

Zielgruppe

Research

Autoren/Hrsg.

Giordano, Antonio

Soprano, Kenneth J

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakotherapie, Psychopharmakotherapie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Onkologie, Krebsforschung

Inhaltsverzeichnis

1 Cdk Inhibitors: Background and Introduction.- 2 p27, A Prognostic Indicator Reflecting?.- 3 Cell Cycle Control of Transcription at the G1/S Phase Transition.- 4 Tumor-Suppressor Genes as Diagnostic Tools.- 5 Regulation of Cell Cycle and Apoptosis.- 6 CDK Inhibitors as Targets of Chemoprevention Agents.- 7 Cell Cycle Regulatory Genes as Targets of Retinoids.- 8 Modulators of Cyclin-Dependent Kinases: A Novel Therapeutic Approach for the Treatment of Neoplastic Diseases.- 9 Cell Cycle Regulators: Interactions and Their Role in Diagnosis, Prognosis, and Treatment of Cancer.- 10 Cell Cycle Regulators as Targets of Anticancer Therapy.- 11 Mammalian CDK Inhibitors as Targets of Ubiquitinization in Cancer.- 12 Synthetic Oligopeptides as Cancer Cell Cycle Modulators.