Geller Advances in Clinical Trial Biostatistics

Erscheinungsjahr 2003
ISBN: 978-0-203-91288-1
Verlag: Taylor & Francis
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 271 Seiten

Reihe: Chapman & Hall/CRC Biostatistics Series

From aspects of early trials to complex modeling problems, Advances in Clinical Trial Biostatistics summarizes current methodologies used in the design and analysis of clinical trials. Its chapters, contributed by internationally renowned methodologists experienced in clinical trials, address topics that include Bayesian methods for phase I clinical trials, adaptive two-stage clinical trials, and the design and analysis of cluster randomization trials, trials with multiple endpoints, and therapeutic equivalence trials. Other discussions explore Bayesian reporting, methods incorporating compliance in treatment evaluation, and statistical issues emerging from clinical trials in HIV infection.

Zielgruppe

Biostatisticians, statistical clinical trialists, statistical drug developers and researchers, and graduate students in these disciplines

Autoren/Hrsg.

Geller, Nancy L.

Fachgebiete

• Naturwissenschaften Biowissenschaften Biowissenschaften
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Pharmazeutische Technologie

Inhaltsverzeichnis

Bayesian Methods for Cancer Phase I Clinical Trials
James S. Babb and André Rogatko
Design of Early Trials in Stem Cell Transplantation: A Hybrid Frequentist-Bayesian Approach
Nancy L. Geller, Dean Follmann, Eric S. Leifer, and Shelly L. Carter
Design and Analysis of Therapeutic Equivalence Trials
Richard M. Simon
Adaptive Two-Stage Clinical Trials
Michael A. Proschan
Design and Analysis of Cluster Randomization Trials
David M. Zucker
Design and Analysis of Clinical Trials with Multiple Endpoints
Nancy L. Geller
Subgroups and Interactions
Dean Follmann
A Class of Permutation Tests for Some Two-Sample Survival Data Problems
Joanna H. Shih and Michael P. Fay
Bayesian Reporting of Clinical Trials
Simon Weeden, Laurence S. Freedman, and Mahesh Parmar
Methods Incorporating Compliance in Treatment Evaluation
Juni Palmgren and Els Goetghebeur
Analysis of Longitudinal Data with Missingness
Paul S. Albert and Margaret C. Wu
Statistical Issues Emerging from Clinical Trials in HIV Infection
Abdel Babiker and Ann Sarah Walker