Genetic Basis for Respiratory Control Disorders

2008
ISBN: 978-0-387-70764-8
Verlag: Springer US

Buch, Englisch, 324 Seiten, Format (B × H): 160 mm x 241 mm, Gewicht: 705 g

Bringing together top-level contributions on all aspects of the subject, this book provides an overview of the recent advances in the genetics of respiratory control in health and disease. It also shows how combined studies in humans and mouse models have helped to improve our understanding of the mechanisms that underlie genetically determined respiratory control disorders with the goal of developing new therapeutic interventions.

Zielgruppe

Research

Autoren/Hrsg.

Gaultier, Claude

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft
• Sozialwissenschaften Psychologie Allgemeine Psychologie Biologische Psychologie, Neuropsychologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Pädiatrie, Neonatologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Humangenetik
• Naturwissenschaften Biowissenschaften Molekularbiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Chirurgie Herz- & Thoraxchirurgie
• Naturwissenschaften Biowissenschaften Biowissenschaften Neurobiologie, Verhaltensbiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Pneumologie, Atmung, Asthma

Inhaltsverzeichnis

Respiratory control disorders: from genes to patients and back.- Hereditary aspects of respiratory control in health and disease in humans.- Phox2b and the homeostatic brain.- Congenital central hypoventilation syndrome: from patients to gene discovery.- Structural and functional brain abnormalities in Congenital Central Hypoventilation Syndrome.- In vitro studies of PHOX2B gene mutations in congenital central hypoventilation syndrome.- Sudden infant death syndrome: study of genes pertinent to cardiorespiratory and autonomic regulation.- The genetic basis for obstructive sleep apnea: what role for variation in respiratory control?.- Apnea and irregular breathing in animal models: a physiogenomic approach.- Genetic determinants of respiratory phenotypes in mice.- Genes and development of respiratory rhythm generation.- Transcription factor control of central respiratory neuron development.- Lessons from mutant newborn mice with respiratory control deficits.- Tentative mouse model for the congenital central hypoventilation syndrome: heterozygous phox2b mutant newborn mice.- Respiratory control abnormalities in necdinnull mice: implications for the pathogenesis of Prader-Willi syndrome.- Possible role of bioaminergic systems in the respiratory disorders of Rett syndrome.- Respiratory plasticity following intermittent hypoxia: a guide for novel therapeutic approaches to ventilatory control disorders?.