Gabius / Nagel Lectins and Glycoconjugates in Oncology

Erscheinungsjahr 2012
ISBN: 978-3-642-73662-9
Verlag: Springer
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 224 Seiten, eBook

Cellular glycoconjugates and their specific receptors, e.g. lectins, form a recognitive and informative transfer system that justifies special scientific and clinical attention. In various contributions reviewing the initiation and recent progress in this rapidly developing field advances in clinical oncology are discussed with regard to basic sciences as well as their application in clinical sciences. The approaches comprise reports from diverse fields such as biochemistry, cell biology, pathology and clinical oncology, addressing questions of how tumors grow and spread, and leading to the improvement of clinical management and tumor diagnosis.

Zielgruppe

Research

Autoren/Hrsg.

Gabius, Hans-Joachim

Nagel, Gerd A.

Inhaltsverzeichnis

Sialic Acids as Regulators of Molecular and Cellular Interactions.- Endogenous Lectins of Myeloid and Tumor Cells: Characterization and Biological Implications.- Love to Lectins: Personal History and Priority Hysterics.- Gangliosides in Recognitive Cell Interactions and Carbohydrate-Mediated Biosignalling.- Tumor Imaging: Role of the Target Antigen.- Cell Surface Glycoconjugates Associated with Malignancy/ Metastasis of RAW117 Lymphoma Cells.- Alterations in Cell Surface Carbohydrates Affecting Invasion in vitro.- The Effect of Chemical Deglycosylation of Ricin A-Chain on the Therapeutic Potential of Ricin A-Chain Immunotoxins.- Prospects for the Use of Immunotoxins against Solid Tumour Metastases: Studies in a Syngeneic Rat Model System.- Detection of Endogenous Sugar Binding Proteins in Malignant Tumors Especially in Human Breast Cancer.- Histomorphological Characterization of Carbohydrate-Binding Proteins in Human Lung Cancer.- Endogenous Carbohydrate-Binding Proteins in Neuro-Oncology.- Detection of Receptors for Sulfated Polysaccharides in the Microvasculature of Human Cerebral Tissues and Brain Tumours by Use of Biotinylated Probes.- Receptors for Polysaccharides and Neoglycoproteins in Neoplastic and Inflammatory Intestinal Tissue.- Soluble Lectins and Endothelial Cell Growth Factors.- Loss of Contact-Dependent Inhibition of Growth in Chemically Transformed Fibroblasts.- Immunomodulatory Effects by Mistletoe Lectin.- Immunomodulation by Endogenous ß-Galactoside-Specific Lectins.- The Role of Lectins and Glycoconjugates in Cellular Slime Mold Adhesion.