Fundamentals of Advanced Omics Technologies: From Genes to Metabolites

Volume 63
Erscheinungsjahr 2014
ISBN: 978-0-444-62651-6
Verlag: Elsevier Science

Buch, Englisch, 490 Seiten, Format (B × H): 162 mm x 235 mm, Gewicht: 885 g

Fundamentals of Advanced Omics Technologies: From Genes to Metabolites covers the fundamental aspects of the new instrumental and methodological developments in omics technologies, including those related to genomics, transcriptomics, epigenetics, proteomics and metabolomics, as well as other omics approaches such as glycomics, peptidomics and foodomics. The principal applications are presented in the following complementary volume.

The chapters discuss in detail omics technologies, DNA microarray analysis, next-generation sequencing technologies, genome-wide analysis of methylation and histone modifications, emerging nanotechniques in proteomics, imaging mass spectrometry in proteomics, recent quantitative proteomics approaches, and advances in high-resolution NMR-based metabolomics, as well as MS-based non-targeted metabolomics and metabolome analysis by CE-MS, global glycomics analyses, foodomics, and high resolution analytical tools for quantitative peptidomics. Key aspects related to chemometrics, bioinformatics, data treatment, data integration and systems biology, deep-sequencing data analysis, statistical approaches for the analysis of microarray data, the integration of transcriptome and metabolome data and computational approaches for visualization and integration of omics data are also covered.

Zielgruppe

<p>Analytical scientists, PhD students and technicians in control laboratories, universities, hospitals, research laboratories and regulation agencies</p>

Autoren/Hrsg.

Weitere Mitwirkende

Simó, Carolina

Cifuentes, Alejandro

García-Cañas, Virginia

Fachgebiete

• Naturwissenschaften Chemie Analytische Chemie

Inhaltsverzeichnis

Genomics, Transcriptomics and Epigenetics1. DNA Microarray Technology: Overview and Current Status, A. Sánchez-Plá2. Challenges and Future Trends in DNA Microarray Analysis, A. Sedighi, P.C.H. Li3. Next Generation Sequencing: New Tools to Solve Old Challenges, I. Gobernado, A. Sanchez-Herranz, A. Jimenez-Escrig4. Omics Tools for the Genome-Wide Analysis of Methylation and Histone Modifications, Josep C. Jiménez-Chillarón, Rubén Díaz, Marta Ramón-KrauelProteomics5. An Overview of Quantitative Proteomic Approaches, A.J. McShane, V. Farrokhi, R. Nemati, S. Li, X. Yao6. Emerging Nanotechniques in Proteomics, N. Dasilva, M. Gonzalez-Gonzalez, P. Diez, R. Jara-Acevedo, L. Lourido, J.M. Sayagues, A. Orfao, M. FuentesCh. 7. Mass Spectrometry Imaging in Proteomics and Metabolomics, B. Balluff, R.J. Carreira, L.A. McDonnellMetabolomics8. Advances in NMR Based Metabolomics, G.A. Nagana Gowda, D. Raftery9. The Role of Mass Spectrometry in Non-Targeted Metabolomics, H.G. Gika, I.D. Wilson, G.A. Theodoridis10. Direct Mass Spectrometry-Based Approaches in Metabolomics, C. Ibáñez, V. García-Cañas, A. Valdés, C. SimóOther Omics Approaches11. Global Glycomics Analysis: Methodologies and Challenges, N.W. Stebbins, R. Sasisekharan12. Applications of Glycan Microarrays to Functional Glycomics, Y.Yu, X. Song, D.F. Smith, R.D. Cummings13. High Resolution Analytical Tools for Quantitative Peptidomics, S. Dasgupta, L.D. FrickerData Treatment, Integration and Systems Biology14. Gene Expression Analysis and Profiling of Microarrays Data and RNA-Sequencing Data, J. De Las Rivas, S. Aibar, B. Roson15. Analysis of Deep Sequencing Data: Insights and Challenges, J.W. Malcom, J.H. Malone16. Bioinformatic Approaches to Increase Proteome Coverage, F.M. Mancuso, S. Cappadona, E. Sabidó17. Transcriptome and Metabolome Data Integration - Technical Requisites for Successful Data Fusion and Visualization, M. Witting, P. Schmitt-Kopplin18. Computational Approaches for Visualization and Integration of Omics Data, V. Sehgal, T.J Moss, P.T. Ram

Über Autor(innen)

García-Cañas, Virginia
Virginia García-Cañas works in the Laboratory of Foodomics on the development of advanced analytical methods for: Foodomics, including Genomics and Transcriptomics; food quality; food safety; and Nutrigenomic studies. Her research covers: i) development of advanced DNA/RNA-based methods for food analysis (genetically-modified organisms, pathogens, etc.), and ii) Nutrigenomic study of the effect of dietary polyphenols on cancer. She has published over 45 SCI papers and 7 book chapters. Her h index is 19 and her works have received over 900 citations (August-2013).

Cifuentes, Alejandro
Alejandro Cifuentes is a Full Research Professor at the National Research Council of Spain (CSIC) in Madrid, Head of the Laboratory of Foodomics and Director of the Metabolomics Platform (International Excellence Campus CSIC + University Autonoma of Madrid). He has been Founding Director of the Institute of Food Science Research and Deputy Director of the Institute of Industrial Fermentations, both belonging to CSIC. Alejandro's activity includes advanced analytical methods development for Foodomics (including transcriptomics, proteomics and metabolomics), food quality and safety, as well as isolation and characterization of natural bioactive compounds and their effect on human health. He holds different national and international awards, is member of the Editorial Board of 17 international journals (including Journal of Chromatography A, Journal of Separation Science, Food Analytical Methods, International Journal of Molecular Sciences, Heliyon, Journal of Pharmaceutical Analysis, etc.), Editor of TrAC-Trends in Analytical Chemistry and Electrophoresis, and Editor-in-Chief of Open Life Sciences. He has published more than 270 SCI papers, 30 books and book chapters and 9 patents. His h index is 70 (Google scholar, June 2020) and his works have received more than 17000 citations. Alejandro has given more than 200 invited lectures in different national and international meetings in Europe, Asia, Africa, America and Oceania. He has defined for the first time in a SCI journal the new discipline of Foodomics.

Simó, Carolina
Carolina Simó is a Tenured Researcher at the National Research Council of Spain (CSIC) in Madrid, she develops her scientific activities in the Laboratory of Foodomics. Her running research lines include: i) Method development using electrophoretic/chromatographic techniques coupled to mass spectrometry for Proteomics and Metabolomics. ii) Food safety assessment, quality control and other features related to food processing, storage, authenticity; iii) Study of the effect of diet on health/disease and the mechanisms of nutrients and bioactive food components at the molecular level. She has published over 50 SCI papers and 10 book chapters. Her h index is 20 and her works have received over 1000 citations (August-2013).